There's this great recurring "Saturday Night Live" skit from several years back where Phil Hartman plays an unfrozen caveman who goes to law school. He pontificates (发表武断的意见) on the American judicial system while marveling at modern technology like "the tiny people in the magic box" (a TV). It fits a common stereotype: Human ancestors were, well, cavemen, and not as smart as we are today. A new hypothesis from a Stanford geneticist tries to turn this stereotype upside down. Human intelligence may have actually peaked before our ancient predecessors ever left Africa, Gerald Crabtree writes in two new journal articles. Genetic mutations during the past several millennia are causing a decline in overall human intellectual and emotional fitness, he says. Evolutionary pressure no longer favors intellect, so the problem is getting worse. He is careful to say that this is taking quite a long time, so it's not like your grandparents are models of brilliance while your children will be cavemen rivaling Hartman's SNL character. But he does maintain that an ancient Athenian, plucked from 1000 BC, would be "among the brightest and most intellectually alive of our colleagues and companions." His central thesis is that each generation produces deleterious (有害的) mutations, so down the line of human history, our intelligence is ever more impaired compared to that of our predecessors. Not surprisingly, the hypothesis, published in the journal Trends in Genetics, has several geneticists scratching their heads. "It takes thousands of genes to build a human brain, and mutations in any one of those can impair that process, that's absolutely true. It's also true that with each new generation, new mutations arise...but Crabtree ignores the other side of the equation, which is selection," said Kevin Mitchell, associate professor at the Smurfit Institute of Genetics at Trinity College Dublin. "Natural selection is incredibly powerful, and it definitely has the ability to weed out new mutations that significantly impair intellectual ability. There are various aspects in these papers that I think are really just thinking about things in a wrong way. " Crabtree said he wanted to examine the cumulative effect of generation-to-generation mutation on intelligence, which is thought to be controlled by many genes. Using indexes that measure X-chromosome (染色体)-related mental retardation, he comes up with between 2,000 and 5,000 genes related to human intellectual ability. Using another index measuring average mutations that arise in each generation of children, he calculates that within 3,000 years, "we have all sustained two or more mutations harmful to our intellectual or emotional stability.""There is a general feeling that evolution constantly improves us, but it only does that if there is selection applied," Crabtree said in an interview. "In this case, it is questionable about how much selection is occurring now compared to the process of optimizing those genes, which occurred in the jungles of Africa 500,000 years ago." There's already evidence for this in other areas, he argues: Take our sense of smell. Humans have far fewer olfactory receptors than other animals, he said—we're guided by our intellect now, not by smell. We can think about where a piece of food came from, how it was processed, which plant it's from, who has been around it, and so on. A dog, on the other hand, simply sniffs something and either eats it or doesn't. Similarly, he believes evolution now selects for other traits—namely, the most healthy and the most immune, not the most intelligent. But geneticists took issue with his claims, not to mention his citations and methods. Mitchell took issue with Crabtree's characterization of genes—he describes them as links in a chain, with incredible overall disruptive power. They're like a bulb on a string of Christmas tree lights that suddenly fails to work, taking out the entire strand with it: "It can be concluded that genes related to intelligence do not operate as a robust network, but rather as links in a chain, failure of any one of which leads to intellectual disability," he writes. Mitchell countered that this ignores other genes that don't cause intellectual disability. "Biological systems are robust to degradation of several different components," Mitchell said. "Evolution has gone to a lot of trouble to craft your genome so it's finely honed to do its job, and it doesn't make sense that you would have all this random mutation in your brain cells. Also, you would have a very high rate of brain cancer."
单选题 According to the passage, "Saturday Night Live" skit is a________.
【正确答案】 A
【答案解析】解析:细节题。根据第一段的描述可知,《周六夜现场》是一档具有调侃风格、以轻松搞笑为目的并结合现今社会话题的滑稽短剧,类似于一些情景喜剧,故[A]为正确答案。根据本剧的性质和内容,可排除[B]“关于人类先祖的纪录片”、[C]“关于异国经历的脱口秀节目”和[D]“关于现代技术的广播节目”。
单选题 Which of the following would Gerald Crabtree most likely DISAGREE with?
【正确答案】 B
【答案解析】解析:态度题。根据第二段和第五段可知,克拉布特认为基因变异在人类智力的衰退过程中起着重要作用,进化过程如今已不再选择更优智力,因此人们再也不像先祖那样在智力的发展方面存在压力,所以与智力有关的基因已不再那么活跃,综上所述,[A]和[C]都是克拉布特认同的观点,故均排除;根据第三段可知,[B]“有害的变异不易变化,且易于清除”与其观点相悖,故选[B];根据第七段可知,克拉布特认为只有自然选择发挥作用时人类才会得到改善,比起五十万年前人类先祖迫于生存而使基因最优化的过程,究竟有多大程度的自然选择正在发生还不确定,因此[D]“进化过程中,自然选择仅在一些场合下起作用”符合其观点,故也排除。
单选题 Kevin Mitchell raises doubts about Gerald Crabtree's hypothesis in all of the following aspects EXCEPT its________.
【正确答案】 A
【答案解析】解析:细节题。根据第十段第一、二句可知,米切尔除了质疑克拉布特采用的研究方法和参考文献外,对其在基因特性的描述上也提出了异议;另外,根据第五段可知,米切尔认为克拉布特在提出进化压力不再对智力有利、与智力有关的基因正在产生更多的有害变异时,并未考虑到进化过程中自然选择的强大作用,其观点比较片面,综上所述,[B]、[C]和[D]都是米切尔对克拉布特的假说提出质疑的具体方面,故都排除;[A]“此假说自相矛盾的本质”未在文中提及,故选[A]。
单选题 Which of the following would be the best title for the passage?
【正确答案】 C
【答案解析】解析:主旨题。作者以一部滑稽短剧开场,借古论今,指出剧中反映了现代人比人类祖先更聪明这一普遍观点,随后笔锋一转,介绍了遗传学家克拉布特提出的新假说,即现代人不一定比他们的祖先聪明,甚至在过去几千年间人类的智力正在逐渐衰退。作者接着介绍了克拉布特的主要观点、实验内容和方法,同时陈述了另一位遗传学家凯文.米切尔对克拉布特假说的反驳。综上所述,[C]“人类智力已经走下坡路了吗?”最能概括全文大意,故为正确答案。[A]“一个与传统见解相左的新假说”只是文章的部分内容,故排除;[B]“基因突变的利与弊”不是两位科学家争论的焦点,故排除;[D]“进化过程与人类智力”是文中辩论的大背景,但辩论双方所聚焦的是这一背景下的基因突变等问题是否造成了人类智力的衰退,故排除;[D]并未凸显辩论的中心词——“衰退”,而且过于宽泛,故也排除。