单选题 Dosageadjustmentsmayberequiredwhenyoufallill，orareunderstress，orwhenquittingsmoking．Underwhatconditionmaythedosageadjustmentsberequired?

• A．生病，应激状态和戒烟时
• B．疾病加重时
• C．体重增加时
• D．病人开始吸烟时
• E．出现副作用时