Skippers must make a report to customs either in person or by telephone if they have any duty-free goods on board, or are carrying prohibited goods including animals______their port of departure.

A、 with regard to
B、 ignorant of
C、 resistant to
D、 irrespective of

【正确答案】 D

【答案解析】解析：题干：不管他们从什么港口启程，船长必须亲自或打电话向海关报告，在船上是否有免税商品或者包括动物在内的禁运品。irrespective of不考虑，不顾及；with regard to关于；ignorant of不懂，不知道；resistant to有抵抗力的。根据题意，本题选D。