单选题 It would be difficult for a man of his political affiliation, ______, to become a senator from the South.
【正确答案】 C
【答案解析】解析：句意是，无论这个人多么有魅力和才能，变为南方的参议员，也就是改变了他的政治从属关系是很困难的。However=no matter how，表示无论，所以正确答案为C。其他三项搭配均不正确。