单选题 ______ how difficult the situation may seem, it is very important to remember that there are others who arein worse situations.

【正确答案】 D
【答案解析】______how difficult the situation may seem是让步状语从句，横线处应填入从属连词。因在difficult the situation may seem中，表语difficult置于主语the situation前，故_____how应是连词词组。故(D)no matter最恰当。no matter how=however。