John Wesley led his young Methodist movement to take a leadership role in many of the political issues of the day, including prison reform and abolitionism; in this way, he ______ many political preachers of the twentieth century.
由“take a leadership role in many of the political issues of the day”可知，John Wesley的政治运动对于后来的政治家是启迪的作用，故本题选择E项。