生物半衰期t1/2=0.693/k,t1/2=0.5h,则K=0.693/0.5h=1.386h-1。30%经肾排泄,剩余70%经肝代谢消除,故药物的肝清除速率常数是1.386h-1×70%=0.97h-1。