【正确答案】 1、has made significant advance in his research    

【答案解析】[考点] ①现在完成时；②词组：make advance in表示“在…取得进展”
[拓展] since last year是典型的现在完成时的时间标志。其他典型时间标志还有already，recently, for two months, in the past five years等。