摘要
目的:挑选出在刚性和形变配准中表现稳定且一致性好的解剖标记,为临床中评估胰腺癌多模态图像配准质量提供定量化指标。方法:选取25例胰腺癌患者,放疗定位CT与MRI T1加权图像分别进行刚性和形变配准。选取左肾上腺、门静脉、腹腔干动脉、肠系膜上动脉、腰椎椎体、下腔静脉和腹主动脉7种解剖标记。分别在定位CT和配准后的MRI图像上勾画解剖标记,统计分析每一种解剖标记的中心点距离,比较刚性和形变配准的差异,并对解剖标记之间进行相关性分析。结果:7种解剖标记的刚性配准差异均值范围为0.405~1.097 cm,形变配准差异均值范围为0.433~0.740 cm。除左肾上腺以外,其他解剖标记的配准结果在刚性与形变配准之间无显著差异。腹腔干动脉和腹主动脉的配准差异在25例患者中最稳定。相关性研究表明,除腹主动脉和下腔静脉以外,所有解剖标记均有独立的意义。结论:使用解剖标记对胰腺癌多模态图像配准质量进行定量化评估是可行的,临床中推荐使用腹腔干动脉和腹主动脉作为评估解剖标记,在刚性和形变配准中均有高稳定性,并且2者相关性较低,可作为独立的评估标准使用。
Objective:To identify the anatomical landmarks with stable and consistent performance in both rigid and deformation registrations,and to investigate the feasibility that take them as the quantitative indexes for quantitative evaluation of multimodality image registration for pancreatic cancer in clinical practice.Methods:Twenty-five patients with pancreatic cancer were selected.Both the rigid and deformation registrations were performed between simulated CT and MRI T1-weighted images.Seven anatomical landmarks,which were left adrenal gland,portal vein,celiac trunk artery,superior mesenteric artery,lumbar vertebral body,inferior vena cava and abdominal aorta,were selected.The anatomical landmarks were marked on the simulated CT and the registered MRI,respectively.The distances between the geometric centers of each anatomical landmarks in two kinds of images were statistically analyzed.The Wilcoxon rank sum test was implemented to compare the differences between rigid and deformation registrations.In addition,the correlations between anatomical landmarks were analyzed as well.Results:The mean distances of centers for the seven anatomical markers under rigid registration ranged from 0.405 cm to 1.097 cm,while they ranged from 0.433 cm to 0.740 cm under deformation registration.There was no significant difference in the registration of anatomical markers between rigid and deformation registration,except the left adrenal gland.The registration differences of celiac trunk artery and abdominal aorta were of most stable in 25 patients.Correlation study showed that all anatomical markers except abdominal aorta and inferior vena cava were independent and significant.Conclusion:It is feasible to quantitatively evaluate the registration quality of multimodality image registration for pancreatic cancer by using anatomical landmarks.It is recommended to use celiac trunk artery and abdominal aorta as the anatomical markers in clinical procedure.They are both stable in rigid and deformation registration,and the correlation between them is low,with means they can be used as independent evaluation criteria.
作者
李婷婷
张玉洁
吴莉莉
黄雅瑜
张建英
LI Tingting;ZHANG Yujie;WU Lili;HUANG Yayu;ZHANG Jianying(Department of Radiation Therapy,Zhongshan Hospital Affiliated to Fudan University,Shanghai 200032,China)
出处
《肿瘤》
CAS
北大核心
2023年第8期655-661,共7页
Tumor
关键词
胰腺癌
图像融合
刚性配准
形变配准
解剖标记
Pancreatic cancer
Image fusion
Rigid registration
Deformation registration
Anatomical landmarks
