摘要
免疫抑制性肿瘤微环境是肿瘤免疫治疗发挥疗效的重要障碍。因此,改善肿瘤微环境以增强免疫反应是提高免疫治疗疗效的关键。基于机体对“外来”抗原强反应,对机体已存在的抗原弱反应的免疫学基本原则,病原体感染可与先天免疫相关受体相结合,增强抗肿瘤免疫应答。病原体疫苗有可能诱导“热”性肿瘤微环境,提高其抗原递呈和T淋巴细胞活化的作用,表现出更高的免疫治疗响应性,并具有较好的安全性。本文总结了病原体疫苗增强肿瘤免疫反应的相关研究,包括混合细菌疫苗、卡介苗、A群链球菌制剂、基于破伤风毒素设计的合成疫苗、修饰改造的牛痘病毒、流感疫苗、EB病毒和COVID-19疫苗,并探讨了病原体疫苗用于肿瘤免疫治疗的可行性、应用前景和面临的挑战。
The immunosuppressive tumor microenvironment is an important obstacle to tumor immunotherapy.Therefore,improving tumor microenvironment to enhance immune response is the key to improving the efficacy of immunotherapy.Based on the basic principle of immunology that the body has a strong response to“foreign”antigens and a weak response to preexisting antigens,pathogen infection can be combined with innate immune-related receptors to enhance the antitumor immune response.Pathogen vaccines can induce a“hot”tumor microenvironment with stronger antigen presentation and T lymphocyte activation,showing a higher response to immunotherapy and having better security.In this review,we summarized the related studies on pathogen vaccine enhancing tumor immune response,including mixed bacterial vaccine,BCG vaccine,OK-432,synthetic vaccines based on tetanus toxin,modified vaccinia virus,influenza vaccine,Epstein-Barr virus and the COVID-19 vaccine.The feasibility,application prospect,and challenges of pathogen vaccine in tumor immunotherapy were discussed.
作者
张晗溪
刘宝瑞
李茹恬
ZHANG Hanxi;LIU Baorui;LI Rutian(The Comprehensive Cancer Center of Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Clinical Cancer Institute of Nanjing University,Nanjing 210008,Jiangsu Province,China)
出处
《肿瘤》
CAS
北大核心
2023年第2期122-131,共10页
Tumor
基金
国家自然科学基金(81672398,81972192)
关键词
肿瘤免疫治疗
病原体疫苗
肿瘤微环境
免疫调节
Tumor immunotherapy
Pathogen vaccine
Tumor microenvironment
Immunoregulation
