摘要
目的:检测宫颈癌患者血清甲状腺激素和甲状腺过氧化物酶抗体(TPO-Ab)水平,并分析其对宫颈癌患者预后的影响。方法:选取2014年1月—2015年5月我院收治的宫颈癌患者58例为研究组,选取同期我院收治的宫颈炎患者50例作为对照组,比较两组血清三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)、TPO-Ab水平,分析研究组血清T3、TPO-Ab水平与临床特征的关系以及对患者3年存活情况的影响。结果:研究组血清T3、T4、FT3、FT4水平低于对照组,差异有统计学意义(P<0.05);研究组血清TSH水平、TPO-Ab水平阳性率高于对照组,差异有统计学意义(P<0.05);宫颈癌患者血清T3水平、TPO-Ab阳性率与临床分期、淋巴结转移、肿瘤大小有关(P<0.05);血清T3低表达组3年总生存率低于T3高表达组,差异有统计学意义(P<0.05);血清TPO-Ab阴性患者3年总生存率高于阳性患者,差异有统计学意义(P<0.05)。结论:血清T3、TPO-Ab可作为宫颈癌预后的生物标记。
Objective:To detect the levels of serum thyroid hormones and thyroid peroxidase antibody(TPOAb)in patients with cervical cancer and analyze their effect on the prognosis of the patients with cervical cancer.Methods:58 patients with cervical cancer admitted to our hospital from January 2014 to May 2015 were selected as a study group,and 50 patients with cervical inflammation admitted to our hospital during the same period were selected as a control group.The levels of serum triiodothyronine(T3),tetraiodothyronine(T4),free triiodothyronine(FT3),free tetraiodothyronine(FT4),thyrotropin(TSH)and TPO-Ab were compared between the two groups.The relationship between serum T3 and TPO Ab levels and clinical characteristics,as well as the effect on the 3-year survival rate of the patients in the study group were analyzed.Results:The levels of serum T3,T4,FT3 and FT4 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The positive rates of serum TSH and TPO-Ab levels in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The positive rates of serum T3 and TPO-Ab levels in the patients with cervical cancer were related with clinical stage,lymph node metastasis,and tumor size(P<0.05).The 3-year overall survival rate of the patients in the low serum T3 expression group was lower than that in the high serum T3 expression group,and the difference was statistically significant(P<0.05).The 3-year overall survival rate of the patients in serum TPO-Ab-negative patients was lower than that in the positive patients,and the difference was statistically significant(P<0.05).Conclusion:Serum T3 and TPO-Ab can be used as biomarkers for the prognosis of cervical cancer.
作者
张冬梅
李明霞
Zhang Dong-mei;Li Ming-xia(Department of Endocrinology,Shenqiu County People’s Hospital,Shenqiu Henan 466300,China;Department of Obstetrics and Gynecology,Shenqiu County People’s Hospital,Shenqiu Henan 466300,China)
出处
《中国合理用药探索》
CAS
2019年第12期41-44,共4页
Chinese Journal of Rational Drug Use
