摘要
目的:探讨磷酸肌酸钠在新生儿脑损伤中的应用效果及对患儿心肌损伤的保护作用。方法:选择2016年5月—2018年3月我院收治的新生儿脑损伤患者82例作为研究对象,按随机数字表法分为对照组和观察组,各41例。对照组给予单唾液酸四己糖神经节苷酯钠液(20 mg,qd)治疗,观察组在对照组基础上联合磷酸肌酸钠(0.5 g,qd)治疗,治疗1周后比较两组治疗效果,比较两组治疗前后肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、肌钙蛋白T(CTnT)水平,比较两组治疗前、治疗后3 d、7 d及2周神经功能及恶心呕吐、躁动、皮疹、肝肾功能异常及腹泻发生率。结果:治疗1周后观察组CK、CK-MB、LDH及CTnT水平均低于对照组,差异有统计学意义(P<0.05);治疗后3 d、7 d及2周观察组神经功能评分均高于对照组,差异有统计学意义(P<0.05);两组恶心呕吐、躁动、皮疹、肝肾功能异常及腹泻发生率比较差异无统计学意义(P>0.05)。结论:磷酸肌酸钠治疗新生儿脑损伤有助于改善患者心肌功能,提高神经功能修复能力,且安全性较高,值得推广应用。
Objective:To explore the application effect of creatine phosphate sodium in neonatal brain injury and its protective effect on myocardial injury in the children.Methods:82 neonates with brain injury admitted to our hospital from May 2016 to March 2018 were selected as subjects investigated,and they were randomly divided into a control group and an observation group,41 cases each.The patients in the control group were treated with tetrahexosaccharide monosalic acid ganglioside sodium(20 mg,qd),and the patients in the observation group were treated with creatine phosphate sodium(0.5 g,qd)on the basis of the treatment in the control group.The therapeutic effect after 1 week of treatment were compared between the two groups.The levels of creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)and Troponin T(CTnT)before and after treatment were compared between the two groups.The neurological function before treatment,3 days,7 days and 2 week after treatment,and the incidences of nausea and vomiting,agitation,rash,liver and kidney dysfunction and diarrhea were compared between the two groups.Results:The levels of CK,CK-MB,LDH and CTnT 1 week after treatment in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The neurological function scores 3 days,7 days and 2 week after treatment in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the incidences of nausea and vomiting,agitation,rash,liver and kidney dysfunction and diarrhea between the two groups(P>0.05).Conclusion:Creatine phosphate sodium can help improve the myocardial function of the patients and improve the ability of nerve function repair in the treatment of neonatal brain injury,and has high safety,which is worth of popularization and application.
作者
张金玉
许俊
张红阳
Zhang Jin-yu;Xu Jun;Zhang Hong-yang(Department of Neonatal Intensive Care,Nanyang First People’s Hospital,Nanyang Henan 473003,China)
出处
《中国合理用药探索》
CAS
2019年第12期1-3,7,共4页
Chinese Journal of Rational Drug Use
关键词
磷酸肌酸钠
单唾液酸四己糖神经节苷酯钠
新生儿脑损伤
心肌功能
神经功能
安全性
Creatine Phosphate Sodium
Tetrahexosaccharide Monosalic Acid Ganglioside Sodium
Neonatal Brain Injury
Myocardial Function
Neurological Function
Safety
