摘要
目的:探究左炔诺孕酮宫内缓释系统(LNG-IUS)联合小剂量米非司酮治疗围绝经期功能失调性子宫出血(简称围绝经期功血)的疗效及对患者雌激素水平的影响。方法:选取我院2016年10月—2018年1月收治的围绝经期功血患者84例,按随机数字表法分为对照组和研究组,各42例。对照组给予LNG-IUS治疗,在此基础上,研究组加用小剂量米非司酮片(10 mg,qd)治疗,均连续服用6个月。比较两组临床疗效及治疗前后的月经失血图(PBAC)评分、雌激素、子宫内膜厚度等指标水平差异。结果:研究组临床疗效高于对照组,差异有统计学意义(P<0.05);治疗后,研究组卵泡刺激素(FSH)、雌二醇(E2)、黄体酮激素(LH)及孕酮(P)均低于对照组,差异有统计学意义(P<0.01);治疗后1,3,6月,研究组各时点的PBAC评分以及子宫内膜厚度均低于对照组,差异有统计学意义(P<0.05)。结论:LNG-IUS联合小剂量米非司酮治疗围绝经期功血的疗效确切,可有效改善患者的月经量、子宫内膜厚度以及雌激素水平,值得临床推荐。
Objective:To investigate the efficacy of levonorgestrel-releasing intrauterine system(LNG-IUS)combined with low-dose mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding and its effect on estrogen levels in the patients.Methods:84 patients with perimenopausal dysfunctional uterine bleeding admitted to our hospital from October 2016 to January 2018 were selected and randomly divided into a control group and a study group,42 cases each.The patients in the control group were treated with LNG-IUS.On this basis,the patients in the study group were treated with low-dose mifepristone tablets(10 mg,qd)for 6 months.The clinical efficacy and the differences in menstrual blood loss chart(PBAC)score,estrogen,endometrial thickness and other indexes before and after treatment were compared between the two groups.Results:The clinical efficacy in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of follicle stimulating hormone(FSH),estradiol(E2),progesterone hormone(LH)and progesterone(P)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 1,2,3,6 months of treatment,the PBAC score and endometrial thickness at each time point in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:LNG-IUS combined with low-dose mifepristone is effective in the treatment of perimenopausal dysfunctional uterine bleeding,which can effectively improve the menstrual flow,endometrial thickness and estrogen level of the patients,and is worthy of clinical recommendation.
作者
丁玉玲
Ding Yu-ling(Department of Obstetrics and Gynecology,Jiyuan Maternal and Child Health Hospital,Jiyuan Henan 459000,China)
出处
《中国合理用药探索》
CAS
2019年第10期104-107,共4页
Chinese Journal of Rational Drug Use
