摘要
目的:观察不同剂量的加减白虎加人参汤颗粒治疗2型糖尿病(火热炽盛型)的临床疗效及安全性。方法:将99例初次诊断为2型糖尿病(火热炽盛型)的患者随机分为低剂量组(30例)、中剂量组(32例)、高剂量组(31例)。各试验组予以基础治疗联合不同剂量的加减白虎加人参汤颗粒,上述治疗持续8 w。治疗前、治疗第4 w和治疗结束时,分别抽取患者的静脉血,对空腹血糖(Fasting plasma glucose,FPG)、餐后2 h血糖(Two hour postprandial glucose,2 hPG)含量、糖化血红蛋白(Glycosylated hemoglobin,HbA1c)进行测定;对治疗前、治疗结束时的中医临床疗效进行评估。结果:治疗结束时,低剂量组总有效率为66.67%,中剂量组总有效率为84.38%,高剂量组总有效率为93.55%,总有效率随着剂量增加而增高(P<0.05);各组血清HbA1c值随着剂量增加明显降低(P<0.05)。在治疗第4 w和治疗结束时,各组的血清FPG、2 hPG值随着剂量增加而明显降低(P<0.05)。同一试验组不同治疗阶段的血清FPG、2 hPG值,随着治疗时间的延长明显降低(P<0.05)。各组治疗前后安全性指标无差异。结论:在基础治疗上使用不同剂量的加减白虎加人参汤颗粒治疗2型糖尿病(火热炽盛型)对FPG、2 hPG、HbA1c和中医疗效等指标的改善均有一定的效果,且与中药的剂量呈正相关。
Objective:To observe the clinical efficacy and safety of different doses of Modified Baihu Renshen Granules(加减白虎加人参汤颗粒)in the treatment of type 2 diabetes mellitus(T2DM)of Huorechisheng(火热炽盛)syndrome.Methods:A total of 99 patients initially diagnosed with T2DM of Huorechisheng(火热炽盛)syndrome were randomized into low-dose group(30 cases),medium-dose group(32 cases),and high-dose group(31 cases).Each experimental group was given basic treatment combined with different doses of Modified Baihu Renshen Granules(加减白虎加人参汤颗粒),and the administration lasted 8 weeks.Before treatment,at the 4th week of treatment,and after treatment,venous blood of the patients was collected,respectively,and then levels of fasting plasma glucose(FPG),two-hour postprandial glucose(2 hPG),and glycosylated hemoglobin(HbA1c)were determined.The clinical efficacy of traditional Chinese medicine was evaluated before and after treatment.Results:At the end of treatment,the total effective rate was 66.67%in low-dose group,84.38%in medium-dose group,and 93.55%in high-dose group,which increased with the dose(P<0.05).The serum HbA1c value significantly decreased with the increase of dose(P<0.05).At the 4th week and the end of treatment,the FPG and 2 hPG values significantly reduced with the rise of dose(P<0.05).The values of FPG and 2 hPG in the same experimental group decreased over the treatment time(P<0.05).No significant difference was observed in clinical safety indexes in each group before and after treatment.Conclusion:On the basis of basic treatment,different doses of Modified Baihu Renshen Granules(加减白虎加人参汤颗粒)can improve FPG,2 hPG,HbA1c,and TCM efficacy in the treatment of T2DM of Huorechisheng(火热炽盛)syndrome,which is positively correlated with the dose.
作者
李慧
冯皓月
岳仁宋
何成诗
张美林
袁松柏
夏晓辉
黄玲玲
杨蕻
张新霞
Li Hui;Feng Haoyue;Yue Rensong;He Chengshi;Zhang Meilin;Yuan Songbai;Xia Xiaohui;Huang Lingling;Yang Hong;Zhang Xinxia(School of Acupuncture and Moxibustion,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611731;Hospital of Chengdu University of TCM,Chengdu 610075)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2022年第1期172-176,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
四川省科技厅重点研发项目(编号:2017SZ0072)
关键词
加减白虎加人参汤颗粒
2型糖尿病
量效关系
临床研究
Modified Baihu Renshen Granules(加减白虎加人参汤颗粒)
Type 2 diabetes Mellitus
Dose-effect relationship
Clinical research
