摘要
目的探讨血清中α-谷胱甘肽转移酶和α-羟丁酸脱氢酶水平对妊娠期内胆汁淤积产妇围生期母婴结局的关系。方法选取本院2016年6月至2018年6月间在我院治疗的妊娠期肝内胆汁淤积产妇作为研究对象,设为观察组。根据患者肝功能受损程度分为轻度组与重度组;选择同期入院孕检者128例,设为对照组。观察组入院后日次早晨空腹取静脉血3mL,对照组孕检当天空腹取静脉血3mL,检测三组患者血清中生化指标,探讨血清中α-谷胱甘肽转移酶和α-羟丁酸脱氢酶生化指标与妊娠肝内胆汁淤积产妇围生期母婴结局的关系。结果观察组与对照组TB水平比较差异无统计学意义(P>0.05);观察组ALT、AST、TBA、DB、a-GST、a-HBDH水平,均高于对照组(P<0.05);重度组与轻度组TB水平比较差异无统计学意义(P>0.05);重度组ALT、AST、TBA、DB、a-GST、a-HBDH水平,均高于轻度组(P<0.05);观察组胎儿窘迫率、早产率、剖宫产率、羊水II°以上污染率分别为16%、25%、73%、18%,明显高于对照组患者,而分娩孕周、新生儿出生体重、产后出血量对比无差异,logistic回归分析结果提示以早产为终点事件时,a-GST、a-HBDH水平为独立早产的独立风险因素,以胎膜早破为终点事件时,TBA、a-HBDH、a-GST为胎膜早破的独立风险因素,以羊水污染为终点事件时,TBA、a-GST、a-HBDH为羊水污染的独立风险因素,以胎儿窘迫为终点事件时,a-GST、a-HBDH为胎儿窘迫的独立风险因素。结论α-谷胱甘肽转移酶和α-羟丁酸脱氢酶水平是妊娠期肝内胆汁淤积产妇围生期母婴不良结局的独立风险因素,应加强二者水平测定,改善妊娠结局,值得推广应用。
Objective:To investigate the relationship between glutathione S-transferase alpha and alpha hydroxybutyrate dehydrogenase levels and intrahepatic cholestasis of pregnancy maternal perinatal outcome.Method:Intrahepatic cholestasis of pregnant women treatment of bile in pregnancy in our hospital from June 2016 to June 2018 were selected as the research object,according to the degree of liver function damage were divided into mild group and severe group,the two groups were detected in the serum biochemical indexes,to investigate the relationship between serum alpha hydroxybutyrate dehydrogenase glutathione enzyme and biochemical index and liver alpha cholestasis maternal perinatal outcome of pregnancy.Results:The patients in the observation group were ALT,AST,TBA,a-GST,a-HBDH levels were 190.5±89.6,151.6±75.4,25.6±12.6,258.4±85.4,48.6±22.6,169.6±82.6,significantly higher than in the control group,the observation group the incidence of fetal distress,premature delivery rate,cesarean section rate,amniotic fluid pollution rate above II degrees were 16%,25%,73%,18%,significantly higher than in the control group,and gestational age,birth weight,postpartum hemorrhage had no difference in comparison with the results of logistic regression analysis showed premature for the end of the event,a-GST and a-HBDH level are independent risk factors of preterm birth independently,premature rupture of membrane as the endpoint when the independent risk factors for TBA,a-HBDH,a-GST for the prom,the amniotic fluid pollution as the endpoint,independent risk factors for TBA,a-GST,a-HBDH pollution of amniotic fluid,fetal distress for the end of the event,a-GST,a-H BDH independent risk factor for fetal distress.Conclusion:Carbamazepine can control the pregnancy in patients with epilepsy seizures,combined with folic acid treatment,can reduce the rate of fetal malformation.
作者
罗艳
吕红
袁琼
黄玉普
LUO Yan;LU Hong;YUAN Qiong;HUANG Yu-pu(Pujiang people′s Hospital of Chengdu Third People′s Hospital,Chengdu 611630;Sichuan Second Hospital of traditional Chinese medicine,Chengdu 610031)
出处
《中国优生与遗传杂志》
2020年第9期1116-1118,1129,共4页
Chinese Journal of Birth Health & Heredity
基金
项目名称:益生菌治疗妊娠期妇女便秘疗效与安全性的系统评价,项目编号:18PJ531
