摘要
目的探讨外周血白细胞(WBC)、C反应蛋白(CRP)及胎盘白细胞检测与妊娠期高血压疾病的相关性。方法选择我院产科于2016年5月至2019年5月收治的50例妊娠期高血压孕妇作为观察组,另匹配选择我科同期收治规律产检的50例正常孕妇作为对照组。比较两组外周血WBC、CRP和胎盘白细胞浸润情况,采用Spearman分析法对各指标与妊娠期高血压相关性进行分析。采用二元Logistic回归对妊娠期妇女发生高血压的危险因素进行多因素分析。结果观察组孕产妇外周血WBC(7.70±1.63 vs 5.71±2.02)、CRP(5.52±1.93 vs 2.90±1.32)水平及存在胎盘白细胞浸润比例(40.0%vs 82.0%)显著高于对照组,差异具有统计学意义(P<0.05)。Spearman分析发现,外周血WBC、CRP水平及胎盘白细胞浸润与妊娠期高血压的发生呈正相关(P<0.01),相关系数分别为0.813、0.864和0.761。二元Logistic回归分析表明,外周血WBC(OR=2.118,95%CI:1.370~3.273)、CRP(OR=2.616,95%CI:1.663~4.114)水平及胎盘白细胞浸润(OR=5.079,95%CI:1.419~18.176)是妊娠期高血压发生的独立危险因素。结论外周血WBC、CRP和胎盘白细胞浸润与妊娠期高血压的发生显著相关,全身炎症反应很可能是导致妊娠期妇女发生高血压的重要因素。
Objective:To explore the correlation between the detection of peripheral blood leukocytes(WBC),C-reactive protein(CRP)and placental leukocytes and hypertension during pregnancy.Methods:50 pregnant women with pregnancy-induced hypertension who were admitted to the obstetrics department of our hospital from May 2016 to May 2019 were selected as the observation group,and 50 normal pregnant women who were admitted to our department during the same period of regular obstetric examination were selected as the control group.The peripheral blood WBC,CRP and placental leukocyte infiltration were compared between the two groups.Spearman analysis was used to analyze the correlation between each index and hypertension in pregnancy.Multivariate analysis of risk factors for hypertension in pregnant women using binary logistic regression.Results:The levels of WBC(7.701.63 vs 5.712.02)and CRP(5.521.93 vs 2.901.32)and the percentage of placental leukocyte infiltration in the observation group(40.0%vs 82.0%)were significantly higher than those in the control group.Academic significance(P<0.05).Spearman analysis found that peripheral blood WBC,CRP levels and placental leukocyte infiltration were positively correlated with the occurrence of pregnancy-induced hypertension(P<0.01),and the correlation coefficients were 0.813,0.864,and 0.761,respectively.Binary Logistic regression analysis showed that peripheral blood WBC(OR=2.118,95%CI:1.370~3.273),CRP(OR=2.616,95%CI:1.663~4.114)levels and placental leukocyte infiltration(OR=5.079,95%CI:1.419~18.176)is an independent risk factor for hypertension during pregnancy.Conclusion:Peripheral blood WBC,CRP and placental leukocyte infiltration are significantly related to the occurrence of hypertension in pregnancy.Systemic inflammatory response is likely to be an important factor leading to hypertension in pregnant women.
作者
高志敏
孙莎
杜巍
贺利红
GAO Zhi-min;SUN Sha;DU Wei;HE Li-hong(Partment of Obstetrics,petrochina Central Hospital,065000,Langfang,Hebei;Partment Of Obstetrics And Gynecology,Maternal And Child Health Hospital,Guangyang District,Langfang City,065000,Langfang,Hebei Province)
出处
《中国优生与遗传杂志》
2020年第9期1098-1100,1148,共4页
Chinese Journal of Birth Health & Heredity
基金
廊坊市科技支撑计划项目(2016013010)
