摘要
目的对2015-2019年广西围产儿神经管缺陷监测资料进行回顾性分析,了解近5年广西围产儿神经管缺陷的发生情况,为下一步的预防干预措施提供科学依据。方法采用以医院监测为基础的监测方案,监测对象为在监测医院内出生的妊娠满28w至出生后7天的围产儿。结果2015-2019年广西围产儿神经管缺陷总发生率为0.82/万,5年间神经管畸形发生率呈下降趋势,降幅达30.51%,其中女性发生率为0.91/万,男性发生率为0.69/万,女性发生率高于男性。无脑畸形、脊柱裂、脑膨出发生率分别为0.28/万、0.42/万、0.13/万;不同产母年龄组神经管缺陷的发生率不同(P<0.05),产母年龄<20岁组和≥35岁组神经管缺陷的发生率较高。围产儿神经管缺陷产前诊断的比例为63.64%,孕28w前诊断的比例为17.9%。结论2015-2019年广西围产儿神经管缺陷发生率呈下降趋势,加强产前诊断工作是进一步降低围产儿神经管缺陷发生率的有效措施。
Objective:Using retrospective method to analyze the monitoring data of neural tube defects of perinatal infants in Guangxi from 2015 to 2019,so as to understand the occurrence of neural tube defects in Guangxi in recent 5 years,and to provide scientific basis for the next step of prevention and intervention measures.Methods:The monitoring was based on hospital network,and the monitoring subjects were the perinatal infants born in the monitoring hospitals from 28 weeks to 7 days after birth.Results:The total incidence of neural tube defects in Guangxi from 2015 to 2019 was 0.82/10000,and the total incidence of neural tube defects decreased by 30.51%in five years.The total incidence of neural tube defects of female was 0.91/10000 and that of male was 0.69/10000,and the total incidence of female was higher than that of male.The incidence of anencephaly,spina bifida and encephalocele was 0.28/10000,0.42/10000 and 0.13/10000,respectively.The total incidence of neural tube defects was different in different birth age groups(P<0.05).The total incidence of neural tube defects was higher in the age<20 years old and≥35 years old of pregnant mothers.The rate of prenatal diagnosis of neural tube defects in perinatal infants was 63.64%,and that before 28 weeks of gestation was 17.9%.Conclusions:The total incidence of neural tube defects in Guangxi from 2015 to 2019 shows a downward trend.And the effective measures to further reduce the incidence of neural tube defects in perinatal infants is to strengthen the prenatal diagnosis。
作者
韦洁
梁丽芳
陈碧艳
彭振仁
黄秀宁
韦慧
宋鹏书
丘小霞
何升
WEI Jie;LIANG Lifang;CHEN Bi-yan(Guangxi Zhuang Autonomous Region Women and Children Care Hospital,Zip code:530000)
出处
《中国优生与遗传杂志》
2020年第6期738-740,共3页
Chinese Journal of Birth Health & Heredity
基金
广西医疗卫生适宜技术与推广应用项目(S201614)
国家重点研发专项(2018YFC1002501)
关键词
神经管缺陷
围产儿
发生率
Neural Tube Defects
Perinatal
Incidence
