摘要
目的了解滕州市2011-2019年出生缺陷发生状况及变化趋势,为制定和完善有针对性出生缺陷预防对策及干预措施提供科学依据。方法根据《中国出生缺陷监测方案》,对滕州市2011-2019年2所监测医院出生的239415例围产儿出生缺陷监测进行统计分析。结果滕州市2011-2019年共监测围产儿239415例,出生缺陷儿2845例,发生率118.83/万,9年间出生缺陷发生率整体呈上升趋势,2017年呈现拐点,上升趋势降低。男性围产儿出生缺陷发生率(133.77/万)高于女性(100.33/万),城市围产儿出生缺陷发生率(136.41/万)高于农村(114.30/万),差异均有统计学意义(P<0.05)。产妇年龄<20岁及≥35岁两个年龄组孕产妇所生围产儿出生缺陷发生率明显高于其他年龄组,前四位主要出生缺陷类型依次为先天性心脏病(21.01/万)、多指/趾(15.87/万)、唇裂(7.02/万)、尿道下裂(4.01/万)。先天性心脏病发生率呈上升趋势,2015年呈现拐点,上升趋势降低。多指/趾发生率呈上升趋势、唇裂发生率呈下降趋势,9年间未出现明显的拐点,尿道下裂发生率呈下降趋势,2013年呈现拐点,下降趋势增加。结论滕州市出生缺陷发生率总体呈上升趋势,但2017年之后上升趋势降低,先天性心脏病的发生率呈上升趋势且跃居首位,应加强出生缺陷综合防控,规范开展围产期保健服务,减少出生缺陷发生。
Objective:To understand the occurrence and change trend of birth defects in Tengzhou from 2011 to 2019,and to provide scientific basis for formulating and improving the prevention and intervention measures of targeted birth defects.Methods:According to the program of birth defects monitoring in China,239415 cases of perinatal birth defects in two monitoring hospitals in Tengzhou from 2011 to 2019 were analyzed.Results:From 2011 to 2019,239415 perinatal and 2845 birth defects were monitored in Tengzhou City,with the incidence of 11883/10000.The incidence of birth defects increased in 9 years.In 2017,the incidence of birth defects showed a turning point and the rising trend decreased.The incidence of perinatal birth defects in male(133.77/10000)was higher than that in female(100.33/10000),while that in urban(136.41/10000)was higher than that in rural(114.30/10000),the difference was statistically significant(P<0.05).The incidence of perinatal birth defects was significantly higher in the two age groups with maternal age<20 and≥35 than in other age groups.The first four major types of birth defects were congenital heart disease(21001/10000),multiple fingers/toes(1587/10000),cleft lip(702/10000)and hypospadias(401/10000).The incidence of congenital heart disease is on the rise.In 2015,the incidence of congenital heart disease is turning point,and the rising trend is decreasing.The incidence of polydactyly/toe showed an upward trend,the incidence of cleft lip showed a downward trend,there was no obvious inflection point in 9 years,the incidence of hypospadias showed a downward trend,the inflection point in 2013,the downward trend increased.Conclusion:The incidence of birth defects in Tengzhou City is generally on the rise,but after 2017,it is on the decline,and the incidence of congenital heart disease is on the rise and ranks first.We should strengthen the comprehensive prevention and control of birth defects,standardize the development of perinatal health care services,and reduce the incidence of birth defects.
作者
方超
FANG Chao(Department of Health care,Maternal and Child Information,Tengzhou Maternal and Child Health Hospital,Tengzhou,Shandong,277500)
出处
《中国优生与遗传杂志》
2020年第4期503-508,共6页
Chinese Journal of Birth Health & Heredity
关键词
围产儿
出生缺陷
医院监测
变化趋势
Perinatal
Birth defects
Hospital monitoring
Change trend
