摘要
目的分析色素减退蕈样肉芽肿的临床表现、组织病理特征及治疗。方法对2018年至2021年诊断为色素减退蕈样肉芽肿的34例患者进行了为期5年的回顾性研究。纳入研究的临床均表现为色素减退斑并经皮肤活检确诊。采用的治疗方式包括窄带UVB和/或外用药物,例如氮芥和外用皮质类固醇。结果在研究数据中,大多数病例HMF发病发生在儿童期和青春期。在免疫组织化学分析中,大多数情况下检测到主要是CD8+浸润。对于处于1A期的患者,治疗包括光疗和局部用药。结论在这项研究中,色素减退蕈样肉芽肿与经典蕈样肉芽肿有不同的表现,主要表现为年轻人群,进展较慢,大多数患者仍在I期接受治疗。然而,我们观察到任何病变的色素沉着都是治疗方案有效性的指标。
Objective To analyse the clinical manifestations,histopathological features and the treatment of hypopigmented mycosis fungides(HMF).Methods The clinical and histopathological features of 34 patients with HMF treated in ho.5-year retrospective review based on medical records of patients with a diagnosis of hypopigmented mycosis fungoides(from 2018 to 2021)was conducted.All 34 patients were collected in the department of dermatology at Hangzhou Third People’s Hospital.Inclusion of this study required the presence of hypopigmented skin lesions and skin biopsy diagnosis of hypopigmented mycosis fungoides.Treatment modalities employed include narrowband UVB and/or topical medications such as nitrogen mustard and topical corticosteroids.Results HMF onset occurred in childhood and adolescence in most of the cases in research data.On immunohistochemical analysis a predominantly CD8+infiltrate was detected in the majority of cases.For patients presenting in stage 1A,treatment includes phototherapy and topical medication.Conclusion Hypopigmented mycosis fungoides affected skin of colour patients in this study.This variant has a different presentation from classic mycosis fungoides,with a predominantly younger population,slower progression,and most patients still receiving treatment in stage I.However,we observed that the pigmentation of any lesion is an indication of the effectiveness of the treatment regimen.
作者
沈宏
徐俊珠
王彦红
朱惠军
俞婉婷
许爱娥
SHEN Hong;XU Junzhu;WANG Yanhong;ZHU Huijun;YU Wanting;XU Ai'e(Department of Dermatdogy,Third People's Hospital of Hangzhou,Hangzhou 310009,China)
出处
《皮肤科学通报》
2022年第4期335-338,7,共5页
Dermatology Bulletin
关键词
蕈样肉芽肿
临床特征
治疗
Mycosis fungoides
Clinical features
Treatment
