摘要
原发性肝癌是我国发病率高、死亡率高、危害极大的恶性肿瘤之一,严重威胁我国人民健康和生命。目前肝癌临床上常用的治疗方法包括手术、介入、化疗及放疗等,但在应用过程中也发现很多不足,如复发率高、化疗药物不敏感及耐药、患者术后生活质量低等。现代医学研究发现中医中药在化疗药物减毒增敏及提高患者生活质量等方面均发挥出重要作用。肿瘤细胞糖代谢重编程是指肿瘤细胞即便在氧气充足的情况下也依靠糖酵解供能,同时产生大量乳酸,被称为“瓦伯格(Warburg)效应”。对肝癌细胞的糖代谢重编程特点进行详细论述,并从“脾气散精”理论解释中医中药缓解肝癌症状及提高患者生存率方面的科学理论,旨在为肝癌的综合性治疗提供新思路和新方案。
Hepatocelluar carcinoma is one of the malignant tumors with high incidence and great harm in China.At present,commonly clinical treatment methods include surgery,intervention,chemotherapy and radiotherapy,etc.,but many deficiencies are also found in the clinical process,such as high recurrence rate,insensitivity and drug resistance of chemotherapy drugs and low postoperative quality of life of patients.Modern research has found that TCM plays an important role in improving patients’symptoms and quality of life.The reprogramming of glucose metabolism in tumor cells refers to the fact that tumor cells rely on glycolysis for energy even when oxygen is sufficient,while producing large amounts of lactic acid,known as the“Warburg effect”.In this paper,the reprogramming characteristics of glucose metabolism in hepatocellular carcinoma cells were discussed in detail,and the scientific theory of relieving symptoms of hepatocellular carcinoma and improving survival rate of patients with traditional Chinese medicine is explained in combination with the theory of“spleen Qi dispersing essence”,aiming at providing new ideas and schemes for comprehensive treatment of hepatocellular carcinoma.
作者
翟亚荣
吴瑶
王杰
裘雪莹
孟嘉伟
陈丝
王群
王俊岩
宋囡
贾连群
ZHAI Yarong;WU Yao;WANG Jie;QIU Xueying;MENG Jiawei;CHEN Si;WANG Qun;WANG Junyan;SONG Nan;JIA Lianqun(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Translational Medicine Research Center of Traditional Chinese Medicine in Liaoning Province,Shenyang 110847,Liaoning,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第5期168-171,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金(81974548,82074145)
辽宁省“兴辽人才”计划(XLYC1902100)
关键词
脾气散精
原发性肝癌
糖代谢重编程
磷酸戊糖途径
spleen Qi dispersing essence
hepatocelluar carcinoma
reprogramming of glucose metabolism
PPP
