摘要
目的探讨升阳益胃汤联合子午流注择时耳穴贴压法对慢性萎缩性胃炎(chronic atrophic gastritis,CAG)患者胃蛋白酶原、炎性指标、微小RNA-26a(miR-26a)及微小RNA-32(miR-32)表达的影响。方法选取诊治的CAG患者100例,随机分为对照组与观察组,每组50例,以西医四联疗法为基础,对照组采用子午流注择时耳穴贴压法治疗,观察组采用升阳益胃汤联合子午流注择时耳穴贴压法治疗,疗程2个月,观察治疗前后中医证候积分变化,血清胃蛋白酶原水平及炎性指标变化及miR-26a及miR-32表达变化。结果两组治疗前中医证候主症及次症积分、血清胃蛋白酶原I和胃蛋白酶原II、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)及miR-26a、miR-32表达量比较差异无统计学意义(P>0.05)。治疗后较治疗前中医证候积分下降,且观察组下降幅度大于对照组,比较差异有统计学意义(P<0.05);胃蛋白酶原I和胃蛋白酶原II治疗后较治疗前升高,且观察组升高幅度大于对照组,IL-2、IL-6、TNF-α治疗后较治疗前下降,且观察组下降幅度大于对照组,比较差异有统计学意义(P<0.05);治疗后较治疗前miR-26a升高,且观察组高于对照组,miR-32治疗后较治疗前下降,且观察组低于对照组,比较差异有统计学意义(P<0.05);对照组治疗总有效率为80.00%(40/50),观察组治疗总有效率为94.00%(47/50),比较差异有统计学意义(P<0.05)。结论升阳益胃汤联合子午流注择时耳穴贴压法治疗CAG能明显有助于改善症状及胃蛋白酶原水平,减轻炎症反应,调节miR-26a及miR-32表达,提高治疗疗效。
Objective To discuss the effect of Shengyang Yiwei Decoction(升阳益胃汤)combined with midnight-noon ebb-flow theory and auricular application on the levels of pepsinogen and inflammatory markers and expressions of miR-26a and miR-32 in patients with chronic atrophic gastritis(CAG).Methods A total of 100 patients with CAG were randomly divided into the control group and the observation group,50 cases in each group.The routine quadruple therapy was the basis treatment.The control group was treated with midnight-noon ebb-flow theory and auricular application and the observation group was treated with Shengyang Yiwei Decoction combined with midnight-noon ebb-flow theory and auricular application.The two groups were treated for 2 months.TCM syndrome scores,serum levels of pepsinogen and inflammatory markers and the expressions of miR-26a and miR-32 of two groups were observed before and after treatment.Results There was no significant difference between the two groups in the main and secondary scores of TCM syndromes,serum levels of pepsinogen I,pepsinogen II,interleukin-2(IL-2),interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)or the expression levels of miR-26a and miR-32 before treatment(P>0.05).The scores of TCM syndromes were decreased after treatment compared with those before treatment,and the decrease amplitude of the observation group was larger than that of the control group and the difference was statistically significant(P<0.05).The levels of pepsinogen I and pepsinogen II after treatment were higher than those before treatment,and those of the observation group were higher than those in the control group and the difference was statistically significant(P<0.05).The levels of IL-2,IL-6 and TNF-αwere decreased after treatment compared with those before treatment,and the decrease amplitude of the observation group was larger than that of the control group.The difference was statistically significant(P<0.05).The expression of miR-26a after treatment was higher than that before treatment and that of the observation group was higher than that in the control group.The expression of miR-32 was decreased after treatment compared with that before treatment,and the decrease amplitude of the observation group was larger than that of the control group.The difference was statistically significant(P<0.05).The total effective rate was 80.00%(40/50)in the control group and 94.00%(47/50)in the observation group and the difference was statistically significant(P<0.05).Conclusion Shengyang Yiwei Decoction combined with midnight-noon ebb-flow theory and auricular application in the treatment of CAG can significantly help to improve the symptoms and pepsinogen level,relieve the inflammatory reaction,regulate the expressions of miR-26a and mir-32 and improve the therapeutic effect.
作者
陈贤
刘京
郝杰
孟令静
毛宇湘
CHEN Xian;LIU Jing;HAO Jie;MENG Lingjing;MAO Yuxiang(Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,Hebei,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第5期248-251,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河北省中医药管理局项目(2020023)
关键词
慢性萎缩性胃炎
升阳益胃汤
子午流注
耳穴贴压
胃蛋白酶原
炎性因子
miR-26a
miR-32
chronic atrophic gastritis
Shengyang Yiwei Decoction(升阳益胃汤)
midnight-noon ebb-flow theory
auricular application
pepsinogen
inflammatory markers
miR-26a
miR-32
