摘要
目的观察阳黄清解颗粒配合高压氧治疗新生儿感染性黄疸的临床疗效。方法选取我院2015年5月至2017年6月收治的91例新生儿感染性黄疸患儿,按照随机数字表法分为对照组和治疗组,对照组45例采用基础治疗及高压氧治疗,治疗组46例在对照组治疗方法的基础上加用阳黄清解颗粒治疗,10 d后观察比较2组的临床疗效。结果治疗组总有效率为91.30%,对照组为66.67%,2组比较,差异有统计学意义(P<0.01)。治疗前2组血清总胆红素水平及黄疸指数经统计学分析,差异无统计学意义(P>0.05),具有可比性。治疗后2组血清总胆红素水平及黄疸指数均显著下降,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组下降更显著(P<0.05)。治疗前2组血清降钙素原(PCT)、C-反应蛋白(CRP)水平经统计学分析,差异无统计学意义(P>0.05),具有可比性。治疗后2组血清PCT、CRP水平均下降显著,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组下降更显著(P<0.05)。治疗组血清总胆红素恢复正常时间及黄疸消退时间均较对照组短,2组比较,差异有统计学意义(P<0.05)。结论阳黄清解颗粒配合高压氧治疗新生儿感染性黄疸,可改善患儿血清PCT、CRP、总胆红素水平及黄疸指数,缩短总胆红素恢复正常时间及黄疸消退时间,效果显著,安全性高,值得临床推广应用。
Objective To observe the clinical efficacy of Yanghuang Qingjie Keli(阳黄清解颗粒)combined with hyperbaric oxygen in treating heonate infants with infectious jaundice.Methods A total of 91 cases of infectious jaundice in our hospital from May 2015 to June 2017 were divided into control group and treatment group according to random number table.The control group with 45 cases was given basic treatment and hyperbaric oxygen,while the treatment group with 46 cases was added with Yanghuang Qingjie Keli on the basis of the control group.The clinical efficacy in the 2 groups was observed and compared 10 days later.Results The total effective rate of the treatment group was 91.30%,which was higher than 66.67%of the control group,and the difference was statistically significant(P<0.01).According to statistics analysis the serum level of total bilirubin,jaundice indexes in the2 groups before treatment had no statistical difference(P>0.05),and the data had good comparability.The serum level of total bilirubin,jaundice indexes in the 2 groups decreased significantly after treatment,there was statistical significance compared with those in the 2 groups before treatment(P<0.01),and the treatment group decreased more significantly(P<0.05).Serum PCT and CRP levels in the 2 groups before treatment had no statistical significance according to statistics analysis(P>0.05),and the data had good comparability.Serum PCT and CRP levels in the 2 groups decreased significantly after treatment compared with those in the 2 groups before treatment(P<0.01),and the treatment group decreased more significantly(P<0.05).Recovery time of the serum level of total bilirubin and regression time of the jaundice in the treatment group was shorter than that of the control group,there was statistical significance between the 2 groups(P<0.05).Conclusion Yanghuang Qingjie Keli combined with hyperbaric oxygen in treating neonatal infectious jaundice can improve the levels of PCT,CRP and serum total bilirubin and icteric index,shorten recovery time of total bilirubin and promote regression time of the jaundice.It is effective and safe,which is worthy of clinical application and promotion.
作者
檀满祥
江龙
陆薇薇
TAN Manxiang;JIANG Long;LU Weiwei(Pedioctrics Department,Anji Maternal and Child Health Care Hospital,Anji,Zhejiang,313300,China)
出处
《中医儿科杂志》
2018年第6期64-67,共4页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
感染性黄疸
新生儿
阳黄清解颗粒
高压氧
降钙素原
C-反应蛋白
临床观察
infectious jaundice
neonate
Yanghuang Qingjie Keli(阳黄清解颗粒)
hyperbaric oxygen
procalcitonin
C-reactive protein
clinical observation
