摘要
目的观察消食健脾合剂辅助治疗小儿功能性消化不良(FD)脾虚型的临床疗效及对血清胃动素(MOT)、神经肽(NPY)、5-羟色胺(5-HT)的影响。方法选取我院2015年1月至2016年12月收治的FD脾虚型患儿84例,采用数字表法随机分为对照组和治疗组,各42例。对照组采用复方阿嗪米特治疗,治疗组在对照组治疗方法的基础上联合消食健脾合剂治疗,1月后比较2组的临床疗效、治疗前后血清MOT、NPY、5-HT的水平及不良反应情况。结果对照组总有效率为71.4%,治疗组为95.2%,2组比较,差异有统计学意义(P<0.05)。治疗前2组MOT、NPY、5-HT水平比较,差异均无统计学意义(P>0.05),具有可比性;治疗后2组MOT、NPY水平明显升高,5-HT水平明显下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高或下降幅度大于对照组(P<0.05)。2组在治疗过程中均未出现严重不良反应。结论消食健脾合剂辅助治疗小儿FD脾虚型临床疗效显著,可有效改善患儿MOT、NPY、5-HT水平,且安全性高,值得临床推广应用。
Objective To observe the clinical efficacy of Xiaoshi Jianpi Heji in adjunctive treatment of functional dyspepsia with spleen deficiency in children and its effect on MOT,NPY and 5-HT as well.Methods Eighty-four children with functional dyspepsia and spleen deficiency admitted to our hospital from January 2015 to December 2016 were chosen and randomly divided into control group and treatment group by random number table method,42 cases in each one.The control group was treated with compound azintamide,while the treatment group was added with Xiaoshi Jianpi Heji(消食健脾合剂)on the basis of the control group.Then the clinical efficacy,serum motilin(MOT),neuropeptide(NPY)and 5-hydroxytryptamine(5-HT)levels and adverse reactions in both groups after 1 month were compared before and after treatment.Results The total effective rate of the treatment group was 95.2%,while that of the control group was 71.4%,there was statistical significance between the 2 groups(P<0.05).There was no significant difference between the 2 groups in MOT,NPY and 5-HT levels before treatment(P>0.05),and they were comparable.After treatment,MOT and NPY levels were significantly increased,while the level of 5-HT was significantly decreased,there was statistical significance compared with the same group before treatment(P<0.05).Moreover,the increase extent and decrease extent of the treatment group was higher than that of the control group(P<0.05).No serious adverse reactions were observed in the 2 groups during the treatment.Conclusion The clinical efficacy of Xiaoshi Jianpi Heji in adjunctive treatment of children with functional dyspepsia and spleen deficiency is significant with a high safety,which can effectively improve the MTL,NPY,5-HT levels of the children.It deserves clinical promotion and application.
作者
张惠玲
ZHANG Huiling(Department of Pediatrics,Tonglu County Hospital of TCM,Tonglu,Zhejiang,311500,China)
出处
《中医儿科杂志》
2018年第6期46-49,共4页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
功能性消化不良
小儿
脾虚型
消食健脾合剂
临床观察
functional dyspepsia
children
spleen deficiency
Xiaoshi Jianpi Heji(消食健脾合剂)
clinical observation
