摘要
口腔扁平苔藓(OLP)是一种病因尚未完全明确的慢性炎症性口腔黏膜疾病。自身免疫性甲状腺疾病(AITD)是一类以甲状腺特异性抗体异常增多为特点的自身免疫性疾病。近年来,越来越多的研究表明,临床上OLP患者伴发AITD的概率呈上升趋势。两者的发生发展可能与口腔角质形成细胞表达甲状腺自身抗原、辅助性T细胞(Th)1/Th2和Th17/调节性T细胞亚群的失衡、滤泡Th细胞和趋化因子数量及功能异常以及CD8+T细胞特异性杀伤靶细胞等有关。本文就OLP与AITD可能共存的免疫机制作一综述,以期从免疫学角度为两者的诊疗提供思路。
Oral lichen planus(OLP)is a chronic inflammatory oral mucosal disease with unclear etiology.Autoimmune thyroid diseases(AITD)is a type of autoimmune disease characterized by increased thyroid-specific antibodies.In recent years,more and more studies have found that the incidence of AITD is increased in OLP patients.The occurrence and development of OLP and AITD may be related to the expression of thyroid autoantigen in oral keratinocytes,the imbalance of thyroid hormone(Th)1/Th2 and Th17/Treg cell subsets,the abnormal quantity and function of follicular helper T cells and chemokines and the specific killing ability of CD8+T cells to target cells.In this article,the possible immune mechanisms involved in the coexistence of OLP and AITD are reviewed to provide insights for the diagnosis,treatment and prevention of these two diseases from the perspective of immunology.
作者
王雅慧
郝一龙
唐帆
陈谦明
WANG Yahui;HAO Yilong;TANG Fan;CHEN Qianming(Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine&Clinical Research Center for Oral Diseases of Zhejiang Province,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Hangzhou 310006,China)
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2021年第2期222-228,共7页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金创新研究群体项目(82001047)
浙江省重点研发计划(2021C03074)
