摘要
[目的]评估城市癌症早诊早治项目中肺癌高危风险预警模型评估效果,为建立适合中国人群的肺癌早诊早治模型提供理论基础。[方法]采取整群随机抽样的方法,于2014年1月至2018年12月选取徐州市区28个社区93751人进行肺癌高危风险问卷调查及风险评估。评估为肺癌高危风险者将免费接受肺癌的临床筛查。[结果]肺癌高风险组肺癌发生的比率(0.42%,72/17193)高于非高风险组(0.17%,132/76558),差异有统计学意义(P<0.01);分层分析发现:男性和女性、年龄<50岁和≥50岁以及未参加LDCT筛查人群中,肺癌高风险组的肺癌发生比率均高于非高风险组,差异有统计学意义(P<0.01)。高危预警模型在肺癌发病的预测中的敏感性为35.29%(72/204),特异性为81.70(76426/93547)。[结论]利用城市癌症筛查项目所建立的肺癌高危风险预警模型对发现高风险人群有一定作用。
[Purpose]To evaluate the application of lung cancer risk assessment model for Cancer Screening Program in Urban China.[Methods]The random cluster sampling method was used to select 93751 people from the 28 communities in Xuzhou city from January 2014 to December2018,all subjects underwent questionnaire survey and the risk of lung cancer was assessed.Those who were assessed as high-risk of lung cancer would receive free clinical screening for lung cancer.[Results]The incidence rate of lung cancer in the high risk group(0.42%,72/17193)was higher than that in the non-high-risk group(0.17%,132/76558)(P<0.01).The stratified analysis showed that the incidence rate of lung cancer in high-risk group of lung cancer was higher than that in the non-high-risk group both the males and females,those aged<50 and aged≥50 years and the people who did not participate in low dose CT(LDCT)screening(all P<0.01).The sensitivity of the risk assessment model of lung cancer was 35.29%(72/204)and the specificity was 81.70%(76426/93547).[Conclusion]The risk assessment model of lung cancer is of certain effectiveness for Cancer Screening Program in Urban China.
作者
罗小虎
王健
董栋
孔蕴馨
李霓
冯小双
LUO Xiao-hu;WANG Jian;DONG Dong;KONG Yun-xin;LI Ni;FENG Xiao-shuang(Xuzhou Tumor Hospital,Xuzhou 221000,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中国肿瘤》
CAS
CSCD
北大核心
2020年第3期167-171,共5页
China Cancer
关键词
癌症筛查
风险评估
肺癌
模型
江苏
cancer screening
high-risk assessment
lung cancer
model
Jiangsu
