摘要
双膦酸盐性颌骨骨坏死(bisphosphonate related osteonecrosis of the jaws,BRONJ)发生于使用双膦酸盐治疗的骨质疏松症、骨转移癌和其他骨破坏性疾病患者中,是一种严重的颌骨坏死。双膦酸盐与骨组织中的矿物质有很强的亲和力,能在骨吸收的过程中进入破骨细胞并产生毒性作用,从而抑制破骨细胞的分化与代谢,因此双膦酸盐具有明显的抗骨吸收的作用。双膦酸盐根据其侧链的不同而分为含氮以及非含氮两大类,含氮类双膦酸盐比非含氮类双膦酸盐具有更强的抗骨吸收的作用。Marx在2003年首次报道了静脉注射唑来膦酸会导致颌骨坏死,从那以后双膦酸盐颌骨骨坏死在国际上引起了广泛的重视。然而关于双膦酸盐引起骨坏死的具体机制尚不明确,本文将对双膦酸盐颌骨骨坏死的机制进行综述。
Bisphosphonated osteonecrosis of the jaws(BRONJ)is a severe osteonecrosis of the jaw that occurs in patients treated with bisphosphonates for osteoporosis,metastatic bone cancer,and other bone destructive diseases.Bisphosphonates have strong affinity with minerals in bone tissue,and can enter osteoclasts and produce toxic effects in the process of bone resorption,thereby inhibiting the differentiation and metabolism of osteoclasts,so bisphosphonates have obvious anti-bone resorption effect.Bisphosphonates can be divided into nitrogen-containing and non-nitrogen-containing groups according to their side chains.Nitrogen-containing bisphosphonates have a stronger anti-bone resorption effect than non-nitrogen-based bisphosphonates.Marx first reported that intravenous injection of zoledronic acid could cause osteonecrosis of the jaw in 2003.Since then,bisphosphonate osteonecrosis of the jaw has attracted wide attention in the world.However,the specific mechanism of bisphosphonate-induced osteonecrosis is not clear,this article will review the mechanism of bisphosphonate-induced osteonecrosis of jaw.
作者
赵玲帆
叶鑫鑫
张强
ZHAO Ling-fan;YE Xin-xin;ZHANG Qiang(Dept.of Oral and Maxillofacial Surgery,First Affiliated Hospital of Nanchang University,Nanchang 330006,China)
出处
《中华老年口腔医学杂志》
2023年第1期50-55,共6页
Chinese Journal of Geriatric Dentistry
基金
国家自然科学基金(81560189,81260169)
关键词
双膦酸盐
破骨细胞
骨坏死
炎症
治疗与预防
机制
Bisphosphonates
Osteoclast
Osteonecrosis
Inflammation
Treatment and prevention
Mechanism
