摘要
目的探析小儿重症支原体肺炎应用甲泼尼龙琥珀酸钠的辅治效果。方法纳入本次研究的对象均从吉林市儿童医院2017年1月-2019年9月收治的重症肺炎支原体肺炎患儿中选取。通过纳入和排除标准筛选106例,分成对照组和观察组。对照组给予阿奇霉素治疗。观察组给予阿奇霉素+甲泼尼龙琥珀酸钠治疗。对疗效、肺功能指标、促炎因子、抗炎因子及康复速度等进行观察和统计学对比。结果统计分析两组治疗后组间总有效率观察组更高,差异有统计学意义(P<0.05)。统计分析两组治疗后组间FEV_(1)、FVC、PEFR、MEF_(25)、MEF_(50)、MEF_(75)观察组更高,差异有统计学意义(P<0.05)。统计分析两组治疗后组间IL-1β、IL-6、TNF-α、IL-4、IFN-γ观察组更低,差异有统计学意义(P<0.05)。统计分析两组治疗后组间退热时间、肺内啰音消失时间、肺部阴影消失时间、住院时间观察组更短,差异有统计学意义(P<0.05)。结论小儿重症支原体肺炎应用甲泼尼龙琥珀酸钠的辅治效果明显,对肺功能指标的改善程度较大,可有效消除炎症,康复速度快。
Objective To explore adjuvant effect of methylprednisolone sodium succinate on severe mycoplasma pneumonia of children.Methods The paper chose children with severe mycoplasma pneumoniae pneumonia treated in Jilin City Children's Hospital from January 2017 to September 2019 as study subjects.106 cases screened by inclusion and exclusion criteria were divided into control group and observation group.Control group was treated with azithromycin,and observation group with azithromycin+methylprednisolone sodium succinate.Curative effect,pulmonary function index,proinflammatory factors,anti-inflammatory factors and rehabilitation speed were observed and compared statistically.Results Statistical analysis of total effective rate between two groups after treatment showed P<0.05,that of observation group was higher.Statistical analysis of FEV_(1),FVC,PEFR,MEF_(25),MEF_(50)and MEF_(75)between two groups after treatment showed P<0.05,those of observation group were higher.Statistical analysis of IL-1β,IL-6,TNF-α,IL-4,IFN-γbetween two groups after treatment showed P<0.05,those of observation group were lower.Statistical analysis of antipyretic time,disappearance time of pulmonary rales,disappearance time of pulmonary shadows and hospital stay between two groups after treatment showed P<0.05,that of observation group was shorter.Conclusion Methylprednisolone sodium succinate can achieve obvious effect in adjuvant treatment of severe mycoplasma pneumoniae of children,can improve indexes of lung function significantly,eliminate inflammation effectively with fast recovery.
作者
于淼
YU Miao(Pharmacy Department,Jilin City Children's Hospital,Jilin,Jilin,132001)
出处
《智慧健康》
2022年第24期91-95,共5页
Smart Healthcare
关键词
小儿
重症支原体肺炎
甲泼尼龙琥珀酸钠
Children
Severe mycoplasma pneumonia
Methylprednisolone sodium succinate
