摘要
目的探讨对急性心肌梗死(AMI)患者采用不同剂量他汀类药物早期治疗的临床效果。方法收集2015年12月至2020年12月广东省广州市第一人民医院收治的AMI患者临床资料,纳入58例采用阿托伐他汀钙治疗的患者为研究对象,根据用药剂量的不同将58例患者分为观察1组(20mg/d、28例)和观察2组(40mg/d、30例),比较两组生化指标和心脏功能改善情况。结果观察2组用药前总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)水平与观察1组无明显区别(P>0.05);观察2组用药后TC、TG、LDL-C、hs-CRP和IL-6水平均低于观察1组,HDL-C水平高于观察1组(P<0.05)。观察2组用药前室间隔厚度(LVST)、左心室舒张期内径(LVEDD)、左心室收缩期内径(LVESD)和左室射血分数(LVEF)水平与观察1组无明显区别(P>0.05);观察2组用药后LVST、LVESD和LVEDD水平低于观察1组,LVEF水平高于观察1组(P<0.05)。结论以40mg/d的剂量治疗AMI患者可以控制其血脂水平,降低机体炎性指标水平,促进患者心功能的恢复,临床治疗效果显著。
Objective To discuss the early treatment effects with different doses of statins in acute myocardial infarction(AMI)patients.Methods Clinical data about 58 AMI patients of taking atorvastatin calcium(2015.12-2020.12)was collected.According to different drug doses,patients were assigned to observation group 1(20mg/d,28 cases)and observation group 2(40mg/d,30 cases).Biochemical index and cardiac function improvement conditions were compared.Results Before medication,there were no significant between-group differences about total cholesterol(TC),triglyceride(TG),low-density lipoprotein-cholesterol(LDL-C),high-density lipoprotein-cholesterol(HDL-C),hypersensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)(P>0.05);after medication,TC,TG,LDL-C,hs-CRP and IL-6 levels in observation group 2 were lower than observation group 1,but HDL-C levels were higher than observation group 1(P<0.05);before medication,there were no significant between-group differences about left ventricular septum thickness(LVST),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)(P>0.05);after medication,LVST,LVESD and LVEDD values in observation group 2 were lower than observation group 1,but LVEF values were higher than observation group 1(P<0.05).Conclusion 40mg/d atorvastatin calcium can control the blood lipid levels,reduce the inflammatory factors and promote the cardiac function recovery.
作者
邓淑妍
刘婉珊
梁毅
DENG Shu-yan;LIU Wan-shan;LIANG Yi(Pharmaceutical Preparation Department,Guangzhou First People’s Hospital,Guangzhou,Guangdong 510180)
出处
《智慧健康》
2021年第29期151-153,共3页
Smart Healthcare
关键词
急性心肌梗死
阿托伐他汀钙
血脂
炎性因子
心脏功能
Acute myocardial infarction
Atorvastatin calcium
Blood lipid
Inflammatory factors
Cardiac function
