摘要
目的探究比较瑞舒伐他汀与阿托伐他汀治疗冠心病患者的疗效。方法选取2019年4月至2020年10月,在我院接受冠心病治疗的60例患者为研究对象,随机抽签分为对照组和观察组,每组30例,对照组接受阿托伐他汀治疗,观察组接受瑞舒伐他汀治疗。随后比较两组的总有效率,对比两组的TC、LDL-C、HDL-C、CI、LVEDD、CO、LVEF、IMT、Hcy、hs-CRP、不良反应发生率。结果①两组患者临床疗效比较:观察组总有效率高于对照组,差异无统计学意义(P<0.05)。②两组患者血脂水平和心功能比较:两组患者比较,血脂水平(TG、TC、LDL-C、HDL-C)的指标差异无统计学意义(P>0.05),但观察组心功能(CI、LVEDD、CO、LVEF)优于对照组(P<0.05)。③两组患者实验室指标比较:两组患者实验室指标比较,观察组IMT、Hcy、hs-CRP优于对照组(P<0.05)。④两组患者不良反应比较:观察组患者的不良反应率低于对照组(P<0.05)。结论两类药物的降脂效果同样明显,但针对冠心病患者而言,接受瑞舒伐他汀的治疗效果明显,不良反应更少,更值得应用和推广。
Objective To compare the efficacy of rosuvastatin and atorvastatin in the treatment of coronary heart disease.Methods Sixty patients with coronary heart disease treated in our hospital from April 2019 to October 2020 were selected and randomly divided into control group and observation group,30 cases in each group.Then the total effective rate,TC,LDL-C,HDL-C,CI,LVEDD,CO,LVEF,IMT,Hcy,hs-CRP and the incidence of adverse reactions were compared between the two groups.Results①The clinical efficacy of the two groups was compared:the total effective rate of the observation group was higher than that of the control group,and the difference was not statistically significant(P<0.05).②Comparison of blood lipid level and cardiac function between the two groups:there was no significant difference in blood lipid level(TG,TC,LDL-C,HDL-C)between the two groups(P>0.05),but the cardiac function(CI,LVEDD,CO,LVEF)of the observation group was better than that of the control group(P<0.05).③Comparison of laboratory indexes between the two groups:IMT,Hcy and hs-CRP in the observation group were better than those in the control group(P<0.05).④Comparison of adverse reactions between the two groups:the adverse reaction rate of the observation group was lower than that of the control group(P<0.05).Conclusion The lipidlowering effect of two kinds of drugs is also obvious,but the treatment effect of rosuvastatin for patients with coronary heart disease is significant,with less adverse reactions,which is more worthy of application and promotion.
作者
柴文玲
CHAI Wen-ling(Jiuquan People’s Hospital,Jiuquan,Gansu 735300)
出处
《智慧健康》
2021年第11期150-152,共3页
Smart Healthcare
关键词
瑞舒伐他汀
阿托伐他汀
冠心病
不良反应
血脂
Rosuvastatin
Atorvastatin
Coronary heart disease
Adverse reactions
Blood lipid
