摘要
目的对比治疗系统性红斑狼疮(SLE)采用血浆置换法与免疫吸附法对患者SLEDAI指数、ANA滴度指数、免疫球蛋白指标的影响。方法选择我院于2017年1月至2020年1月收治的42例SLE患者展开本次研究,根据治疗方法差异随机分组,形成血浆置换组与免疫吸附组,各21例,治疗分别采取血浆置换与免疫吸附法,对比两组患者治疗前后SLEDAI指数、ANA滴度、免疫球蛋白水平变化,比较治疗效果。结果治疗后,组内对比SLEDAI指数、ANA滴度、免疫球蛋白水平三项指标,两组皆为下降趋势,P<0.05,存在统计学意义;但组间数据对比未见统计学差异,P>0.05。结论SLE治疗中,血浆置换以及免疫吸附治疗法均具有确切效果,但血浆置换法费用昂贵、短期效果好,长期治疗建议选择免疫吸附法。
Objective To compare effect of plasma exchange and immunoadsorption in treatment of systemic lupus erythematosus(SLE)on SLEDAI index,ANA titer index,and immunoglobulin indexes.Methods The paper chose 42 patients with SLE admitted to our hospital from January 2017 to January 2020 for study.According to difference in treatment methods,they were randomly divided into plasma exchange group and immunoadsorption group,21 cases in each group.After treatment of plasma exchange and immunoadsorption method,SLEDAI index,ANA titer,and immunoglobulin level changes of two groups before and after treatment,and treatment effect was compared.Results After treatment,two of three indicators of SLEDAI index,ANA titer,and immunoglobulin levels showed downward trend,P<0.05,which was statistically significant;however,data comparison showed no statistical difference between groups,P>0.05.Conclusion In treatment of SLE,both plasma exchange and immunoadsorption therapy have definite effect,but plasma exchange is expensive and can achieve good short-term effect.For long-term treatment,immunoadsorption is recommended.
作者
陈家良
刘小莲
朱万寿
CHEN Jia-liang;LIU Xiao-lian;ZHU Wan-shou(Department of Hematology and Rheumatology,Gaozhou City People's Hospital,Gaozhou,Guangdong,525200)
出处
《智慧健康》
2021年第9期22-24,共3页
Smart Healthcare
