摘要
目的探究二甲双胍对2型糖尿病合并代谢综合征的临床疗效。方法选取从2018年4月至2019年8月在本市福田梅林社区的谢综合征2型糖尿病合并代谢综合征的113例患者,按照随机数字表法分为观察组(n=57)和对照组(n=56)。对照组给予限制饮食、运动疗法,并给予二甲双胍(500mg/次,3次/d)治疗,观察组在对照组的基础上联合西格列汀治疗(100mg/次,1次/d),治疗6个月后测定两组患者的糖代谢指标(FPG、2h PG、HbA1c、HOMAGIR)、脂代谢指标(TG、TC、HDL-C、LDL-C)、骨质疏松相关因子(BMD、BAP、0C、OPG)、体重指数(BMI)、腰围(WC)、腰臀比以及不良反应发生率。结果治疗后观察组的糖代谢指标、脂代谢指标、骨质疏松相关因子均得到了显著的改善,均优于对照组,P均<0.05;观察组患者的BMI、WC及腰臀比均低于对照组,P<0.05;两组患者的不良反应发生率无统计学差异(P>0.05)。结论二甲双胍联合西格列汀可明显改善2型糖尿病合并代谢综合征患者的糖脂代谢,降低患者的体重,对骨质疏松具有一定的保护作用,且安全有效,值得临床上推广。
Objective To explore the clinical effect of metformin on type 2 diabetes mellitus complicated with metabolic syndrome.Methods 113 patients with metabolic syndrome and type 2 diabetes mellitus in Futian Meilin community from April 2018 to August 2019 were selected and divided into observation group(n=57)and control group(n=56)according to random number table method.The control group was given diet restriction,exercise therapy,and metformin(500 mg/time,three times/day)treatment,while the observation group was combined with sitagliptin treatment(100 mg/time)on the basis of the control group.Once a day,after 6 months of treatment,the glucose metabolism index(FPG,2H PG,HbA1c,HOMAGIR),lipid metabolism index(TG,TC,HDL-C,LDL-C),osteoporosis-related factors(BMD,BAP,0C,OPG),body mass index(BMI),waist circumference(WC),waist-hip ratio and the incidence of adverse reactions were measured in both groups.Results After treatment,the indexes of glucose metabolism,lipid metabolism and related factors of osteoporosis in the observation group were significantly improved,which were superior to those in the control group,P<0.05;the BMI,WC and waist-to-hip ratio of the patients in the observation group were lower than those in the control group,P<0.05;there was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Metformin combined with sitagliptin can significantly improve the glucose and lipid metabolism and reduce the weight of patients with type 2 diabetes mellitus complicated with metabolic syndrome,which has a certain protective effect on osteoporosis,and is safe and effective,which is worthy of clinical promotion.
作者
罗浩全
谭清梅
徐红霞
郑启艳
陈宝丽
LUO Hao-quan;TAN Qing-mei;XU Hong-xia;ZHENG Qi-yan;CHEN Bao-li(Shenzhen Futian District Second People’s Hospital,Shenzhen,Guangdong 518000)
出处
《智慧健康》
2020年第19期125-127,130,共4页
Smart Healthcare
基金
2017年深圳市福田区卫生公益性科研项目,项目编号:FTWS049,项目名称:二甲双胍在代谢综合征人群骨质疏松的保护作用
关键词
二甲双胍
2型糖尿病
代谢综合征
糖代谢
脂代谢
Metformin
Type 2 diabetes mellitus
Metabolic syndrome
Glucose metabolism
Lipid metabolism
