摘要
背景与目的目前诱导化疗联合同步放化疗在局部晚期鼻咽癌中的疗效尚不明确。本研究旨在对比TPF方案和TP方案联合同步放化疗在无远处转移局部晚期鼻咽癌患者中的近期疗效和不良反应。方法本研究对局部晚期鼻咽癌患者随机分两组,60例接受TPF方案化疗(多西他赛60mg/m2 d1+顺铂60mg/m2 d1+氟尿嘧啶600mg/m2/d,d1-5静脉维持120h),每21天重复,共3周期。60例接受TP方案化疗(多西他赛60mg/m2 d1+顺铂80mg/m2 d1),每21天重复,共3周期。3程诱导化疗结束后行顺铂联合调强放射治疗。治疗后评价2组不同诱导化疗方案患者的近期疗效及不良反应。结果两组患者在诱导化疗后及治疗后第3个月的有效缓解率差异无统计学意义。TPF组在白细胞下降、肝肾功能损害、腹泻的发生率均明显高于TP组,差异有统计学意义。结论TPF方案诱导化疗治疗局部晚期鼻咽癌的临床疗效与TP方案疗效相当,但TPF方案的不良反应较TP方案明显。
Background and Objective The effect of induction chemotherapy plus concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma is unclear.This study aimed to compare the short-term effects and side effect of induction chemotherapy with TPF versus TP followed by concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma patients with nonmetastatic.Methods In this study,patients with locoregionally advanced nasopharyngeal carcinoma were randomly divided into 2 groups,sixty cases were treated TPF docetaxel at 60 mg/m^2 on day 1,cisplatin at 60 mg/m^2 on day 1,and 5-fluorouracil at a dose of 600 mg/m^2/d by 24 h continuous infusion for 5 days for 3 cycles with a 21 day interval;sixty cases were treated TP docetaxel at 60 mg/m^2 on day 1,cisplatin at 80 mg/m^2 on day 1 for 3 cycles with a 21 day interval.After the completion of 3 cycles induction chemotherapy,all the patients received intensity modulated radiation therapy(IMRT)with concomitant chemotherapy consisting of cisplatin.The short-term effects and side effect of TPF group and TP group were further evaluated after treatment.Results RR of two groups was no statistically significant difference at the end of induction chemotherapy and within 3 months of the completion of concurrent chemoradiotherapy.The incidence of leukopenia,liver and kidney damage and diarrhea in TPF group were significantly higher than those in TP group.Conclusion TPF induction chemotherapy and TP induction chemotherapy have equivalent efficacy in treatment of loregionally advanced nasopharyngeal cainoma patients.But,TPF group has more acute toxicity than TP group.
作者
冯庆
沈冰
黄瑞文
FENG Qing;SHEN Bing;HUANG Rui-wen(Department of Radiotherapy,the Central hospital of Guangdong nongken,Zhanjiang,Guangdong 524002)
出处
《智慧健康》
2020年第10期117-119,共3页
Smart Healthcare
基金
2017年度湛江市第二批非资助科技攻关计划项目(立项编号:2017B01110)
关键词
局部晚期鼻咽癌
诱导化疗
同步放化疗
近期疗效
不良反应
Locoregionally advanced nasopharyngeal carcinoma
Induction chemotherapy
Concurrent chemoradiotherapy
Short-term effects
Side effect
