摘要
目的探讨早期子宫颈腺癌的预后影响因素。方法选择2003年1月至2013年5月在辽宁省肿瘤医院接受手术治疗的早期子宫颈腺癌患者176例,对预后影响因素进行回顾性分析。结果患者中位年龄为45岁(20~73岁),5年总生存率为81.0%,5年无瘤生存率为74%,中位生存时间为85个月。单因素分析显示:临床分期和淋巴结转移与预后有关;ⅠB1、ⅠB2、ⅡA1期5年生存率分别为86%、74%、66%,差异有统计学意义(P<0.05),与ⅠB期患者相比,ⅡA1期的患者死亡风险明显增加(HR=2.92,95%CI 1.37~6.21)。术后病理无淋巴结转移151例,有淋巴结转移25例,5年生存率分别为87.0%、32.0%,差异有统计学意义(HR=8.07,95%CI 4.17~15.61,P<0.05)。多因素分析显示:只有淋巴结转移是预后的独立影响因素(HR=5.86,95%CI 2.85~12.05,P<0.01)。结论早期子宫颈腺癌的5年生存率较高,淋巴结转移是影响早期子宫颈腺癌预后的主要因素。
Objective To investigate the prognostic factors of early stage adenocarcinoma of uterine cervix.Methods Totally 176 cases of early stage adenocarcinoma of uterine cervix who were admitted to Liaoning Cancer Hospital from January 2003 to May 2013 were analyzed retrospectively.Results The median age of 176 cases was 45(20-73),The 5-year overall survival rate was 81%.The 5-year tumor-free survival rate was 74.0%.The median survival time was 85 months.In univariate analysis,prognostic factors of patients with early cervical adenocarcinoma were clinical stage and lymph node metastasis.The five-year survival rate ofⅠB1,ⅠB2 andⅡA1 was 86.0%,74.0%and 66.0%,and there were statistical differences(P<0.05).Compared with patients ofⅠB stage,the risk of death inⅡA1 patients was significantly increased(HR=2.92,95%CI 1.37-6.21).Totally 151 cases were pathologically proved with negative lymph node metastasis and 25 cases positive.The 5-year survival rates of them were 87.0%and 32.0% respectively and there were statistical differences between them(P<0.05).Multivariate analysis showed that only lymph node metastasis was an independent factor for survival(HR=5.86,95%CI 2.85-12.05).Conclusion The 5-year survival rate of early-stage adenocarcinoma of uterine cervix is high;lymphnode metastasis is an important prognostic factor of early stage adenocarcinoma of uterine cervix.
作者
贾海清
王安娜
龙再秋
JIA Hai-qing;WANG An-na;LONG Zai-qiu(Department of Gynecology,Cancer Hospital of China Medical University,Liaoning Cancer Hospital,Shenyang 110042,China)
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2019年第12期1374-1378,共5页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
早期子宫颈腺癌
临床因素
预后
early stage adenocarcinoma of uterine cervix
clinical factors
prognosis
