摘要
目的:分析香格里拉地区肝硬化患者的主要病因及临床特征,为本地区肝硬化的防控提供信息。方法:收集2019年1月至2021年6月期间在云南迪庆藏族自治州人民医院就诊的所有肝硬化患者共104例,回顾性分析患者肝硬化病因的构成比以及主要临床特点等。结果:104例肝硬化患者的年龄为33~86岁,平均年龄为(59.5±11.3)岁;男女比例为9∶4藏族占62.5%,汉族占17.31%,和彝族占15.38%。乙肝Child-Pugh A级38例(37%),B级56例(54%),C级10例(9%);主要临床表现为腹胀。肝硬化病因构成比中,酒精性肝硬化占38%,乙肝肝硬化占48%,丙肝肝硬化占1%,混合性硬化占13%。香格里拉地区肝硬化患者的年龄低于全国其他地区,尤其是酒精性肝硬化患者的发病年龄较其他原因肝硬化年轻,且经规范治疗后疾病缓解率仅为1%。结论:病毒性肝炎仍是我国云南香格里拉地区导致肝硬化的主要病因,酒精性肝病次之,混合性肝硬化占比高。本地区需重视酒精对人体的危害宣教,同时加强病毒性肝炎的防治。
Objective:To analyze the main etiology and clinical features of cirrhosis in Shangri-La area of Yunnan and provide clinical data for prevention and control in such area.Methods:A total of 104 patients with cirrhosis admitted to the People’s Hospital of Diqing Tibetan Autonomous Prefecture from January 2019 to June 2021 were enrolled,and the etiological composition and main clinical characteristics of patients with cirrhosis in Shangri-La were analyzed retrospectively.Results:Patients with cirrhosis ranged from 33 to 86 years old,with an average age of(59.5±11.3)years old.The male to female ratio was 9 to 4.It revealed that 62.5%patients were Tibetans,17.31%were Han Nationality,15.38%were Yi Nationality.For Child-Pugh grading,38 cases(37%)were with Child-PughA,56 cases(54%)were with Child-pugh grade B,and 10 cases(9%)cases were with Child-pugh grade C.The main reason for the visit was abdominal distension.For etiological composition,alcoholic cirrhosis accounted for 38%.Hepatitis B cirrhosis accounted for 48%.Hepatitis C cirrhosis accounted for 1%.Mixed sclerosis accounted for 13%.The age of onset of cirrhosis caused by all causes is younger than those in other parts of the country,especially the age of onset of alcoholic cirrhosis is younger and the prognosis remission rate after standard treatment was only 1%.Conclusions:Viral hepatitis is still the main cause of cirrhosis in this region,followed by alcoholic liver disease and mixed cirrhosis.Attention should be paid to the harm of alcohol to human body education in this region,and strengthen the prevention and treatment of viral hepatitis.
作者
杨文康
张俊
王淑秋
祥巴央宗
杨翠萍
YANG Wenkang;ZHANG Jun;WANG Shuqiu;XIANG BA Yangzong;YANG Cuiping(Department of the Second Internal Medicine,People′s Hospital of Diqing Tibetan Autonomous Prefecture,Yunnan Province 674400,China;Department of Gastroenterology,Ruijin Hospital,Shanghai Jiao Tong University of Medicine,Shanghai 201801,China)
出处
《诊断学理论与实践》
2022年第6期730-734,共5页
Journal of Diagnostics Concepts & Practice
基金
上海市卫生健康委员会科研项目(201940478)
关键词
香格里拉地区
肝硬化
酒精性肝病
肝炎病毒
病因
Shangri-la region
Cirrhosis of the liver
Alcoholic liver disease
Hepatitis virus
Cause
