摘要
急性呼吸窘迫综合征属于危重症,具有非常高的病残率和病死率,对患者的身体健康和生命安全构成严重的威胁。但是关于急性呼吸窘迫综合征的发病机制,医学界尚未形成统一明确的认识,主要认为是多种机制共同作用的结果,包括免疫失衡机制、上皮细胞和内皮损伤机制以及肺纤维化机制等。目前其临床治疗最常用也是最为有效的方式为保护性肺通气策略,具体包括小潮气量通气、呼气末正压、肺复张以及无创正压通气等。为了改善急性呼吸窘迫综合征治疗效果,提高患者存活率,近年来很多专家学者关于急性呼吸窘迫综合征发病机制及通气治疗进展开展了大量研究工作,本文将其进行综述,以期为急性呼吸窘迫综合征的临床治疗提供借鉴。
Acute respiratory distress syndrome(ARDS)is a critical disease with very high disability and mortality,which poses a serious threat to the health and safety of patients.However,there is no clear and unified understanding of the pathogenesis of ARDS,which is mainly attributed to the interaction of multiple mechanisms,including immune imbalance mechanism,epithelial cell and endothelial damage mechanism and pulmonary fibrosis mechanism and so on.At present,the most common and effective way of clinical treatment is protective pulmonary ventilation strategy,including small tidal volume ventilation,positive end-expiratory pressure,lung recruitment and non-invasive positive pressure ventilation and so on.In order to improve the therapeutic effect of ARDS and improve the survival rate of patients,many experts and scholars have carried out a lot of research work on the pathogenesis of ARDS and the progress of ventilation therapy in recent years.This article reviews them in order to provide a reference for the clinical treatment of ARDS.
作者
王峰
WANG Feng(ICU,Binhai Hospital of General Hospital of Tianjin Medical University,Tianjin 300480,China)
出处
《中国城乡企业卫生》
2020年第1期31-33,共3页
Chinese Journal of Urban and Rural Enterprise Hygiene
关键词
急性呼吸窘迫综合征
发病机制
通气治疗
Acute respiratory distress syndrome
Pathogenesis
Ventilation therapy
