摘要
目的了解青海省黄南藏族自治州孕妇碘营养状况,为当地孕妇科学补碘提供依据。方法对青海省多民族聚居的黄南藏族自治州孕妇进行随机抽样,采集尿样进行尿碘浓度检测,静脉血测定甲状腺功能,甲状腺超声测定甲状腺体积和结节。结果最终纳入孕妇306人,随机尿碘浓度中位数为223.95(113.43,596.30)μg/L,其中30.79%和39.30%的受试者尿碘浓度<150μg/L和≥250μg/L。孕妇尿碘浓度<120μg/L比尿碘浓度120~249μg/L组甲状腺结节患病风险趋势增加。甲状腺功能异常率为32.27%,孕妇尿碘浓度≥250μg/L时,发生甲状腺功能异常的风险显著增加(OR=2.63,95%CI:1.07~6.44)。结论尽管青海省黄南藏族自治州孕妇人群尿碘浓度中位数处于适宜水平,但仍有部分孕妇存在缺乏或过量风险。需加强孕妇碘营养监测,提供更精准的碘营养指导建议。
Objective To investigate the iodine status of pregnant women in Huangnan Tibetan Autonomous Prefecture of Qinghai province,and to provide basis for iodine supplementation in local pregnant women.Methods Subjects were randomly sampled in Huangnan Tibetan Autonomous Prefecture of Qinghai Province.Their urine samples were collected for measurement of urinary iodine concentration(UIC).Venous blood was used to measure thyroid function.Thyroid volume and nodules were measured by thyroid ultrasound.Results A total of 306 pregnant women were included.The median UIC of them were 223.95(113.43,596.30)μg/L,and the number of pregnant women with UIC<150μg/L and≥250μg/L were 30.79%and 39.30%,respectively.Pregnant women with UIC<120μg/L had a tendency of increased risk of thyroid nodules compared to those with UIC between 120-249μg/L.The incidence of thyroid dysfunction was 32.27%,and pregnant women with UIC≥250μg/L have an increased risk of thyroid dysfunction(OR=2.63,95%CI:1.07-6.44).Conclusion Although the iodine status of pregnant women in Huangnan Tibetan Autonomous Prefecture of Qinghai Province is at an appropriate level,there are still some pregnant women at risk of iodine deficiency or excess.Iodine nutrition monitoring for pregnant women should be strengthened and more precise iodine nutrition guidance and suggestions are provided.
作者
任志缘
郭文星
甘雨
田瀚
秋忠
王崇丹
张万起
REN Zhi-yuan;GUO Wen-xing;GAN Yu;TIAN Han;QIU Zhong;WANG Chong-dan;ZHANG Wan-qi(Department of Nutrition and Food Hygiene,Tianjin Medical University,Tianjin 300070;Tianjin Binhai New Area Tanggu Obstetrics and Gynecology Hospital,Tianjin 300042;Qinghai Huangnan Tibetan Autonomous Prefecture People's Hospital,Qinghai 811300;Tianjin Environmental Nutrition and Population Health Center,Tianjin 300070,China)
出处
《营养学报》
CAS
CSCD
北大核心
2022年第4期352-356,共5页
Acta Nutrimenta Sinica
基金
国家自然科学基金国际合作项目(No.81920108031)
国家自然科学基金重点项目(No.81330064)
中国营养学会达能基金(No.DIC2020-05)
天津市卫生健康委员会科技项目(No.RK20001)
天津市环境营养与人群健康重点实验室开放课题(No.2020ENKL03)
关键词
碘营养
孕妇
黄南藏族自治州
甲状腺疾病
iodine nutrition
pregnant women
Huangnan Tibetan Autonomous Prefecture
thyroid diseases
