摘要
目的研究副干酪乳杆菌N1115对剖腹产出生婴幼儿肠道健康的影响。方法在爱尔兰招募60名健康的剖腹产出生婴幼儿,年龄6~36月随机分为干预组和对照组,各30名。干预组服用N1115益生菌粉,对照组服用安慰剂,均为每日一袋,连续8w,并观察受试者的大便性状、胃肠症状、肠道菌群、短链脂肪酸以及不良事件发生情况。结果两组均未发生与受试产品相关的不良事件。干预8 w后,干预组的胃肠气胀得分为1.86±2.28,较第0 w时下降,但与对照组比较无显著差异;大便性状、肠道菌群和短链脂肪酸水平,随着时间推移,整个样本集合无明显变化,各组之间没有显著性差异。细分受试者年龄,6~18月龄干预组的大便性状和胃肠气胀情况较对照组有一定差异。结论副干酪乳杆菌N1115对婴幼儿的安全性良好,且对早期的肠道健康可能具有潜在的益生作用.
Objective To study the effect of Lactobacillus paracasei N1115 on intestinal health of infants delivered by caesarean section.Methods Sixty healthy infants delivered by caesarean were aged 6-36 months and recruited in Ireland and randomly divided into two groups(intervention group and control group,with 30 subjects in each group).Subjects in the intervention group were given a daily sachet of N1115 probiotics for 8 weeks,while the control group was given a placebo.The incidence of stool consistency,gastrointestinal symptoms,gut microbiota,short-chain fatty acids and adverse events were observed and recorded.Results There was no adverse event related to the treatment in either group.After 8 weeks of intervention,the score of flatulence in the intervention group was 1.86±2.28,which was lower than at week 0,but was not significantly different from the control group.There was no significant difference between the two groups over time in terms of stool consistency,gut microbiota or short-chain fatty acids.However,there was difference in stool consistency and gastrointestinal symptoms between the infants aged 6 to 18 months and those in the control group.Conclusion Lactobacillus paracasei N1115 is safe for infants,and may be potentially conducive to early intestinal health.[ACTA NUTRIMENTA SINICA,2020,42(4):338-343]
作者
荀一萍
朱宏
冯丽莉
张栋
薛玉玲
王世杰
XUN Yi-ping;ZHU Hong;FENG Li-li;ZHANG Dong;XUE Yu-ling;WANG Shi-jie(Research&Development Center,Shijiazhuang Junlebao Dairy Co.,Ltd.,Shijiazhuang 050221;College of Bioscience&Bioengineering,Hebei University of Science&Technology,Shijiazhuang 050018,China)
出处
《营养学报》
CAS
CSCD
北大核心
2020年第4期338-343,共6页
Acta Nutrimenta Sinica
基金
十三五国家重点研发计划(No.2018YFD0501606,2016YFD0400605)
河北省科技计划项目(No.19942817G)
河北省重点研发计划项目(No.19222812D)
