摘要
目的探讨阿司匹林联合神经节苷脂对脑梗死患者脑血管储备功能及血清视锥蛋白样蛋白-1(visinin-like protein 1,VILIP-1)、血管内皮生长因子(vascular endothelial growth factor,VEGF)的影响。方法选取2020年4月至2022年4月北京市仁和医院收治的110例脑梗死患者作为研究对象,按照随机数字表法分成观察组和对照组,每组55例。两组均接受常规支持治疗,在此基础上给予对照组阿司匹林治疗,观察组在对照组基础上联合神经节苷脂治疗。两组均连续治疗14 d。比较两组临床疗效、Barthel指数评分与美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、脑血管储备功能指标[脑血管储备(cerebrovascular reserve,CVR)、搏动指数(pulsatility index,PI)、屏气指数(breath holding index,BHI)]、血清VILIP-1、VEGF水平与不良反应的差异。结果观察组临床疗效总有效率(96.36%)较对照组(85.45%)高,差异有统计学意义(P<0.05)。两组治疗后Barthel指数评分均高于治疗前,NIHSS评分均低于治疗前,差异有统计学意义(P<0.05),且观察组治疗后Barthel指数评分与对照组比较更高,NIHSS评分与对照组比较更低,差异有统计学意义(P<0.05)。两组治疗后CVR、BHI水平均高于治疗前,PI水平均低于治疗前,差异有统计学意义(P<0.05),且观察组治疗后CVR、BHI水平与对照组比较更高,PI水平与对照组比较更低,差异有统计学意义(P<0.05)。两组治疗后血清VILIP-1、VEGF水平均低于治疗前,且观察组治疗后血清VILIP-1、VEGF水平与对照组比较更低,差异均有统计学意义(P<0.05)。观察组不良反应发生率为3.64%,对照组无不良反应发生,差异无统计学意义(P=0.495)。结论阿司匹林联合神经节苷脂能提升对脑梗死的治疗效果,且可明显改善脑血管储备功能及血清VILIP-1、VEGF水平。
Objective To determine the effects of aspirin combined with gangliosides on cerebral vascular reserve function,and serum visinin-like protein-1(VILIP-1)and vascular endothelial growth factor(VEGF)levels in patients who have had a cerebral infarction.Methods One hundred ten patients who had a cerebral infarction and were admitted to Beijing Renhe Hospital between April 2020 and April 2022 were selected as study objects.The 110 patients were randomly divided into observation(n=55)and control groups(n=55)using a simple random number table.Both groups received routine supportive treatment.The control group was treated with aspirin,while the observation group was treated with gangliosides plus aspirin.Both groups were treated continuously for 14 days.The clinical efficacy,Barthel index score,National Institute of Health stroke scale(NIHSS)score,cerebrovascular reserve function(CVR)index,pulsatility index(PI),breath holding index(BHI),serum VILIP-1 and VEGF levels,and adverse reactions were compared between the two groups.Results Overall clinical efficacy in the observation group(96.36%)was higher than the control group(85.45%)(P<0.05).The Barthel index scores in the observation and control groups were higher after treatment than before treatment(P<0.05),while the NIHSS scores were lower than before treatment(P<0.05).The Barthel index score was higher in the observation group than the control group after treatment,the NIHSS score was lower in the observation group than the control group after treatment(P<0.05).The CVR index and BHI were higher after treatment than before treatment in the observation and control groups(P<0.05),while the PI was lower after treatment than before treatment in the observation and control groups(P<0.05).The CVR index and BHI were higher in the observation group than the control group(P<0.05).And the PI was lower in the observation group than the control group(P<0.05).The serum VILIP-1 and VEGF levels in the observation and controls groups were lower after treatment than before treatment(P<0.05).The serum VILIP-1 and VEGF levels in the observation group were lower than the control group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation and control groups(3.64%vs.0;P=0.495).Conclusions Aspirin combined with gangliosides can enhance the therapeutic effect on cerebral infarction and significantly improve cerebrovascular reserve function,and serum VILIP-1 and VEGF levels.
作者
吴丹
WU Dan(Department of Neurology,Beijing Renhe Hospital,Beijing 102600,China)
出处
《慢性病学杂志》
2023年第5期648-652,共5页
Chronic Pathematology Journal
