摘要
苦参碱能防治二乙基亚硝胺诱发大鼠原发性肝癌和小鼠肝癌H22细胞移植瘤在小鼠体内的生长。体外实验发现苦参碱能浓度相关地抑制肝癌H22细胞、SMMC-7721细胞、BEL-7402细胞、BEL-7404细胞、Hep3B细胞、QGY细胞、QGY/CDDP细胞、97H细胞、CRBH-7919细胞、CRBH-7919/mdr1细胞增殖、黏附、迁移、侵袭并诱导凋亡,也能诱导人肝癌SMMC-7721细胞、BEL-7402细胞、BEL-7404细胞、化学品诱发肝癌大鼠体内的低分化肝卵圆细胞分化,也能提高荷瘤机体的免疫调节功能。临床上苦参碱注射液正在试用于肝癌的治疗和复发的预防。
Matrine has the effects in the prophylaxis and treatment of rat hepatoma induced by diethylnitrosamine,and growth of murine hepatocarcinoma cell H22 transplantation tumor in mice.Matrine inhibits proliferation,adhesion,migration,invasion,and induces apoptosis in association with dosage on hepatoma H22 cells,SMMC-7721 cells,BEL-7702 cells,BEL-7704 cells,Hep3 B cells,QGY cells,QGY/CDDP cells,97 H cells,CRBH-7919 cells,CRBH-7919/mdr1 cells in vitro.Matrine induces differentiation in hepatoma SMMC-7721 cells,BEL-7702 cells,BEL-7404 cells,and poorly differentiated hepatic oval cells too.Matrine elevates immunoregulative function in tumor-bearing body too.In clinical application matrine is being tried to treat and prevent recurrence of heptocarcinoma.
作者
张明发
沈雅琴
ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China)
出处
《药物评价研究》
CAS
2020年第1期157-165,共9页
Drug Evaluation Research
关键词
苦参碱
抗肿瘤
肝癌
药理作用
临床应用
matrine
tumor
hepatoma
pharmacologic effect
clinical application
