摘要
目的探讨产后逐瘀胶囊联合马来酸麦角新碱注射液治疗产后出血的临床疗效。方法选取2018年2月—2019年4月在万宁市人民医院进行治疗的82例产后出血患者为研究对象,根据用药的差别将患者分为观察组(41例)和对照组(41例)。对照组iv马来酸麦角新碱注射液,0.2 mg/次,必要时可2~4 h重复注射1次,最多5次;观察组在对照组基础上给予产后逐瘀胶囊,0.9 g/次,3次/d。两组均治疗4 d。观察两组的临床疗效和产后出血量,同时比较两组治疗前后的血红蛋白(Hb)、D-二聚体(D-D)和纤维蛋白原(FIB)、一氧化氮(NO)、脑钠肽(BNP)、抗凝血酶-Ⅲ(AT-III)水平。结果经治疗,对照组总有效率为80.49%,显著低于的观察组的97.56%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗2 h、2~24 h后,观察组患者产后出血量均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。经治疗,两组Hb、D-D和FIB水平均显著降低,同组治疗前后比较差异具有统计意义(P<0.05);且观察组Hb、D-D和FIB水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。经治疗,两组NO、BNP水平均显著下降,而AT-III表达均增高,同组治疗前后比较差异具有统计学意义(P<0.05);且观察组NO、BNP和AT-III水平均显著优于对照组,两组比较差异具有统计学意义(P<0.05)。结论产后逐瘀胶囊联合马来酸麦角新碱注射液治疗产后出血有着良好的止血作用,有利于改善子宫收缩,促进凝血,利于产后恢复,具有良好临床应用价值。
Objective To explore the clinical effect of Chanhou Zhuyu Capsules combined with Ergometrine Maleate Injection in treatment of postpartum hemorrhage.Methods Patients(82 cases)with postpartum hemorrhage treated in People’s Hospital of Wanning from February 2018 to April 2019 were divided into observation group(41 cases)and control group(41 cases)according to the difference of medication.Patients in the control group were iv administered with Ergometrine Maleate Injection,0.2 mg/time,which could be repeated for 2—4 h if necessary,up to 5 times.Patients in the observation group were given Chanhou Zhuyu Capsules on the basis of the control group,0.9 g/time,three times daily.After treatment,the clinical effects and postpartum hemorrhage amount were observed,and the levels of Hb,D-D,FIB,NO,BNP,and AT-III in two groups before and after treatment were compared.Results After treatment,the effective rate in the control group was 80.49%,which was significantly lower than97.56%in the observation group,and there were differences between two groups(P<0.05).After 2 h and 2—24 h of treatment,the amount of postpartum hemorrhage in the observation group was significantly lower than those in the control group,and there were differences between two groups(P<0.05).After treatment,the levels of Hb,D-D,and FIB in two groups were significantly decreased,and the difference was statistically significant in the same group(P<0.05).And the levels of Hb,D-D,and FIB in the observation group were significantly lower than those in the control group,and there were differences between two groups(P<0.05).After treatment,the levels of NO and BNP in two groups were significantly decreased,while the level of AT-III were increased,and the difference was statistically significant in the same group(P<0.05).And the levels of NO,BNP,and AT-III were significantly better than those in the control group,and there were differences between two groups(P<0.05).Conclusion Chanhou Zhuyu Capsules combined with Ergometrine Maleate Injection has a good hemostatic effect in treatment of postpartum hemorrhage,is conducive to improving uterine contraction,promoting coagulation,conducive to postpartum recovery,which has a good clinical application value.
作者
李小英
杨帅
符浮
LI Xiaoying;YANG Shuai;FU Fu(Department of Obstetrics,People's Hospital of Wanning,Wanning 571500,China;Department of Obstetrics and Gynecology,People's Hospital of Wanning,Wanning 571500,China)
出处
《药物评价研究》
CAS
2020年第1期129-132,共4页
Drug Evaluation Research
基金
万宁市科学研究课题(C03030401).
