摘要
目的:观察扶正祛邪抑癌方联合肝动脉化疗栓塞术(TACE)治疗原发性肝癌中晚期患者的近期临床疗效。方法:采用随机对照研究方法,将50例原发性肝癌中晚期患者分为对照组和治疗组各25例,对照组予以TACE治疗,治疗组在此基础上予以中药复方辨证治疗(扶正祛邪抑癌方为基方),观察两组患者治疗前后生化指标(ALT、AST、GGT、ALP、TBIL、VEGF、AFP)、近期疗效、中医证候积分及KPS评分、安全性指标等。结果:①治疗组治疗后AST、ALT、AFP、VEGF均明显下降(P<0.05),TBIL、GGT、ALP治疗前后比较差异无统计学意义(P>0.05);②近期实体瘤疗效比较:治疗组有效率及稳定率均优于对照组,但两者差异无统计学意义(P>0.05)。③中医证候积分及疗效比较:两组方法均可不同程度改善中晚期肝癌患者的临床症状,但治疗组优于对照组(P<0.05);④KPS评分比较:治疗组治疗后KPS评分明显升高,改善患者生活质量方面优于对照组(P<0.05);⑤两组患者治疗期间均无严重不良反应发生。结论:扶正祛邪抑癌方联合TACE治疗能够明显降低原发性肝癌中晚期患者的肝功能指标、AFP及VEGF水平、临床症状,提高患者生活质量,且安全性高,值得临床推广应用。
Objective:To observe the short-term clinical efficacy of Fuzheng Quxie Yifang Recipe combined with TACE in the treatment of patients with advanced primary liver cancer.Methods:50 patients with advanced primary liver cancer were randomly divided into control group and treatment group,25 cases in each.The control group was treated with TACE.On the basis of this,the treatment group was given a combination of traditional Chinese medicine.The observation period was 6 weeks.The biochemical indicators(ALT,AST,GGT,ALP,TBIL,VEGF,AFP),recent tumor efficacy,TCM syndrome score,KPS score and safety index were observed before and after treatment.Results:①Comparison of biochemical parameters:AST,ALT,AFP and VEGF decreased significantly in the treatment group(P<0.05).There was no significant difference between TBIL,GGT and ALP before and after treatment(P>0.05).②Comparison of recent tumors:The effective rate and stability rate of the treatment group were better than those of the control group,but the difference was not statistically significant(P>0.05).③Comparison of TCM syndrome scores and efficacy:The control group and the treatment group can improve the clinical symptoms of patients with advanced liver cancer in different degrees,but the treatment group is better than the control group(P<0.05);④Comparison of KPS score:After treatment,the KPS score was significantly higher in the treatment group than in the control group(P<0.05).⑤Safety indicators:No serious adverse reactions occurred during the treatment period.Conclusion:Fuzheng Quxie Yifang Recipe combined with TACE can significantly reduce the liver function index,AFP and VEGF levels in patients with advanced primary liver cancer,improve clinical symptoms,improve quality of life,and has good safety.It is worthy of clinical promotion.
作者
王晓栋
李波
蔡丽君
黄素琼
魏嵋
Wang Xiaodong;Li Bo;Cai Lijun;Huang Suqiong;Wei Mei(Department of Hepatobiliary,The Second Affiliated Hospital of Southwest Medical University,Lu Zhou 646000,China)
出处
《亚太传统医药》
2020年第9期151-155,共5页
Asia-Pacific Traditional Medicine
基金
四川省中医药管理局中医药科研专项(2018QN047)
关键词
原发性肝癌
扶正祛邪抑癌方
TACE
近期疗效
Fuzheng Quxie Yifang Recipe
Primary Liver Cancer
TACE
Recent Curative Effect
