摘要
目的探讨中老年2型糖尿病患者伴甲状腺乳头状癌发生淋巴结转移的影响因素。方法纳入2018年7月到2020年10月在郑州大学第一附属医院住院且临床资料完整的2型糖尿病合并甲状腺乳头状癌病例213例,收集患者一般资料及检验检查结果,根据淋巴结转移与否分为转移组和非转移组,对比两组的临床资料情况,非条件Logistic回归模型进行危险因素分析。结果单因素统计分析显示两组间性别、乳酸脱氢酶、超氧化物歧化酶、TAP、肿瘤位置、肿瘤直径、彩超分级差异有统计学意义(P<0.05),两组间超氧化物歧化酶的差异进一步进行组内分析,淋巴结转移组的超氧化物歧化酶水平较正常水平偏低,差异有统计学意义(P<0.0167);Logistic回归分析结果显示性别、TAP、肿瘤位置是淋巴结转移的影响因素。结论中老年2型糖尿病伴甲状腺乳头状癌的男性患者、TAP升高及肿瘤位于双侧者更易出现淋巴结转移。
Objective To explore the influencing factors of lymph node metastasis in middle-aged and elderly patients with type 2 diabetes and papillary thyroid carcinoma.Methods A total of 213 cases of type 2 diabetes complicated with papillary thyroid carcinoma who were hospitalized in the First Affiliated Hospital of Zhengzhou University from July 2018 to October 2020 with complete clinical data were included.General data and examination results of the patients were collected,and they were divided into metastatic group and non-metastatic group according to whether lymph node metastasis was present,and clinical data of the two groups were compared.Risk factors were analyzed by unconditional Logistic regression model.Results Univariate statistical analysis showed that the differences in gender,lactic dehydrogenase,superoxide dismutase,TAP,tumor location,tumor diameter,and ultrasound grade were statistically significant between the two groups(P<0.05).Further intra-group analysis of the differences in superoxide dismutase between the two groups showed that the level of superoxide dismutase in the lymph node metastasis group was lower than the normal level.The difference was statistically significant(P<0.0167).Logistic regression analysis showed that gender,TAP and tumor location were the factors influencing lymph node metastasis.Conclusion Among Middle-aged and elderly men with type 2 diabetes and papillary thyroid carcinoma,those undergoing elevated TAP,and bilateral tumors are more likely to have lymph node metastasis.
作者
李伟芳
李素军
冯涛
李天艺
LI Weifang;LI Sujun;FENG Tao;LI Tianyi(Department of geriatric Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052,China)
出处
《新疆医学》
2024年第5期566-570,共5页
Xinjiang Medical Journal
关键词
糖尿病
2型
甲状腺乳头状癌
淋巴结转移
Diabetes mellitus
type 2 diabetes
Papillaryt hyroid cancer
lymph node metastasis
