摘要
目的探究缬沙坦联合通心络胶囊对扩张型性疾病患者心功能、血管内皮功能及生活质量的影响。方法选92例扩张型性疾病患者,以入院顺序奇偶法分为对照组、观察组,各46例,分别应用缬沙坦、缬沙坦+通心络胶囊治疗,比较组间疗效。结果治疗前两组LVEDd、LVEF、CO水平相近(P>0.05);治疗后LVEF、CO:观察组>对照组;LVEDd:观察组<对照组(P<0.05);治疗前两组VEGF、NO、ET-1水平相近(P>0.05);治疗后NO:观察组>对照组;VEGF、ET-1:观察组<对照组(P<0.05);治疗前两组CQQC(中国心血管病人生活质量评定问卷)评分相近(P>0.05);治疗后CQQC:观察组>对照组(P<0.05);观察组不良反应与对照组相近(10.87%vs 13.04%)。结论对扩张型心肌病患者应用缬沙坦+通心络胶囊治疗,可改善患者心功能及血管内皮功能,改善患者生活质量。
Objective To explore the effect of valsartan combined with Tongxinluo capsule on cardiac function,vascular endothelial function and quality of life in patients with dilated disease.Methods Ninety-two patients with dilated diseases were selected and divided into the control group and the observation group by the odd-even method of admission order,46 cases in each group,respectively,treated with valsartan,valsartan+Tongxinluo capsules,and the efficacy between the groups was compared.Results Before treatment,the levels of LVEDd,LVEF,and CO in the two groups were similar(P>0.05);after treatment,LVEF,COlevels in the observation group were higher than those of control group;LVEDdin the observation groupwas lower thanthat of control group(P<0.05);the levels of VEGF,NO and ET-1 were similar in the two groups before treatment(P>0.05).After treatment,NOlevel in the observation group was higher than thatin control group;VEGF,ET-1 in the observation group waslower thanthat of control group(P<0.05).CQQC(Chinese cardiovascular patients life Quality assessment questionnaire)scores were similar between the two groups before treatment(P>0.05),while CQQCin theobservation groupwas higher than that ofcontrol group after treatment(P<0.05).Adverse reactions in the observation group were similar to those in the control group(10.87%vs 13.04%).Conclusion The application of valsartan+Tongxinluo capsules in the treatment of patients with dilated cardiomyopathy can improve the cardiac function and vascular endothelial function,and improve the quality of life of patients.
作者
卢志超
贾振
LU Zhichao;JIA Zhen(Department ofCardiovascular Medicine,theThird People's Hospitalof Anyang,Anyang,455000,Henan,China)
出处
《新疆医学》
2023年第7期811-813,862,共4页
Xinjiang Medical Journal
