摘要
目的观察双歧三联活菌胶囊联合奥美拉唑治疗小儿急慢性肠胃炎的临床疗效。方法以2018年8月-2019年2月期间南阳市第二人民医院儿科收治并住院治疗的98例急慢性肠胃炎小儿为研究对象,信封法等分为对照组和观察组,对照组给予奥美拉唑(1粒/次,1次/日)治疗,观察组在对照组基础上联合双歧三联活菌胶囊(3粒/次,2次/日),均连续治疗7 d。比较两组小儿临床症状缓解时间、不良反应、血清营养性指标改善情况、胃肠功能GID评级改善情况、生活质量和心理状态改善情况。结果观察组的临床症状(退烧、呕吐消失、腹泻消失)缓解时间均短于对照组(P<0.05);入院时比较,对照组和观察组小儿出院前的血清营养性指标(Hb、ALB、PA)均明显提升,差异具有显著性(P<0.05);观察组小儿出院前的胃肠功能GID分级(Ⅰ级22例,占比44.90%、Ⅱ级18例,占比36.73%)、(Ⅲ级9例,占比18.37%)明显优良于对照组(Ⅰ级22例,占比44.90%、Ⅱ级18例,占比36.73%、Ⅲ级9例,占比18.37%)(P<0.05);与入院时比较,对照组和观察组小儿出院前的生活质量PedsSQL评分明显提升,心理状况a CBCL评分明显下降,但观察组患儿的提升(或下降)幅度更大,差异具有显著性(P<0.05)。结论与单纯奥美拉唑治疗比较,双歧三联活菌胶囊联合奥美拉唑治疗小儿急慢性肠胃炎的疗效确切,可缩短临床症状缓解时间,改善胃肠功能、营养不良症状、病情相关指标、生活质量和心理状况,值得临床推广。
Objective To observe the clinical efficacy of Bifid Triple Viable capsule combined with omeprazole in the treatment of acute and chronic gastroenteritis in children.Methods 98 children with acute and chronic gastroenteritis admitted in thesecond people's hospital ofNanyang from August 2018 to February 2019 were studied.All caseswere divided into control group and observation groupaccording to the envelope method.The control group was treated with omeprazole(capsule per time and1 capsule per day)for7 days,while the observation group was treated with Bifidtriple viable capsule(3 capsules per time and 2 capsules per day)on the basis of the control group for 7 consecutive days.The remission time of clinical symptoms,adverse reactions,improvement of serum nutritional indicators,GID rating of gastrointestinal function,improvement of quality of life and psychological status were compared between the two groups.Results The remission time of clinical symptoms(such as fever,vomitingand diarrhea)in the observation group was shorter than that in the control group(P<0.05),and the serum nutritional indexes(HB,ALB,PA)in both groupsafter treatmentwere significantly higher than those after admission(P<0.05).The GID classification of gastrointestinal function in the observation group(22 cases in grade Iaccounting for 44.90%;18 casesin grade II accounting for 36.73%,and 9 cases in grade IIIaccounting for 18.37%)were significantly better than those in the control group(there were 22 cases in grade Iaccounting for 44.90%,18 cases in grade II accounting for 36.73%,and 9 cases in grade IIIaccounting for 18.37%)(P<0.05).The PedsSQL scores of children in both groups were significantly higher and the psychological status aCBCL scores were significantly lower compared with the admission,and the abovelevels in the observation groupchangesmoreobviously,and the difference was significant(P<0.05).Conclusion Compared with omeprazole alone,Bifid Triple Viable capsule combined with omeprazole in the treatment of acute and chronic gastroenteritis in children has a definite effect.It can shorten the remission time of clinical symptoms,improve gastrointestinal function,malnutrition symptoms,disease-related indicators,quality of life and psychological status.It is worthy of clinical promotion.
作者
范莉姣
张培鑫
陈劲松
FAN Lijiao;ZHANG Peixin;CHEN Jinsong(Department of Pharmacy,the Second People's Hospital of Nanyang,Nanyang,Henan,473000,China)
出处
《新疆医学》
2023年第3期285-289,共5页
Xinjiang Medical Journal
关键词
双歧三联活菌胶囊
奥美拉唑
急慢性肠胃炎
儿童
临床疗效
Bifid triple viable capsule
Omeprazole
Acute and chronic gastroenteritis
Children
Clinical efficacy