摘要
目的探讨25-羟基维生素D(维生素D)缺乏与急性心肌梗死(AMI)之间的关系。方法采用病例-对照研究设计,连续选择2017年1月-2019年5月于新疆维吾尔自治区人民医院住院的AMI患者作为病例组。选取同期住院的非AMI患者作为对照组。收集研究对象住院时测定的血清维生素D值及相关基线资料。比较维生素D水平在两组之间的差异,并运用多元Logistic回归模型分析维生素D与AMI的关系。结果共纳入研究对象186人。病例组79例,平均年龄63.0±9.4岁。对照组107例,平均年龄60.8±9.7岁。病例组血清维生素D平均水平为20.4±6.2ng/mL,对照组为21.0±5.9ng/mL,两组间血清维生素D平均水平差异无统计学意义(P=0.497)。多元Logistic回归分析显示:校正年龄、性别、文化程度、吸烟指数、BMI和合并疾病后,维生素D缺乏者和严重缺乏者AMI的患病风险分别是维生素D正常者的3.35倍(OR=3.35,95%CI:1.30~6.12)和3.8倍(OR=3.80,95%CI:1.41~7.92)。结论25-羟基维生素D缺乏和严重缺乏与AMI的患病风险增加相关,补充维生素D可能有助于治疗和预防AMI。
Objective To investigate the relationship between 25-hydroxyvitamin D deficiency and acute myocardial infarction(AMI).Methods Patients with AMI admitted to the people’s hospital of Xinjiang uygur autonomous region from January 2017 to May2019 were selected as the experimental group.Non-AMI patients at the same period were selected as the control group.Serum vitamin D values and related data were collected.The differences of vitamin D levels between the experimental group and the control group were compared,and the relationship between vitamin D and AMI was analyzed by logistic regression model.Results A total of 186 participants were enrolled.The mean ages of 79 patients in the experimenal group was 63.0±9.4 years old.The mean ages of 107 patients in the control group was 60.8±9.7 years old.The mean serum vitamin D level in the experimental group was 20.4±6.2ng/m L,and that value in the control group was 21.0±5.9ng/m L.There was no significant difference in the average serum vitamin D level between the two groups(P=0.497).Multivariate logistic regression analysis results showed that after adjusting for age,sex,education,smoking index,BMI and comorbidity,compared with normal vitamin D,the risk of AMI was 3.35 folds(OR=3.35,95%CI:1.30~6.12)and 3.8 folds(OR=3.80,95%CI:1.41~7.92)for those with vitamin D deficiency and those with severe deficiency.Conclusions 25-hydroxyl vitamin D deficiency and severe vitamin D deficiency are associated with AMI,and Vitamin D supplements is helpful with AMI treatment and prevention.
作者
张子龙
何林龙
高方明
李国庆
ZHANG Zilong;HE Linlong;GAO Fangming;LI Guoqing(Department of Cardiology,Peoples Hospital of Xinjiang Uygur Autonomous Region,Urumqi,830001,China)
出处
《新疆医学》
2022年第5期560-563,共4页
Xinjiang Medical Journal
