摘要
目的探究乌鲁木齐市空气颗粒物对慢性阻塞性肺疾病(COPD)患者急性加重和肺功能的影响。方法选择2016年至2019年6月本院收治的慢性阻塞性肺疾病患者31例为调查对象,每位受试者入组前需包括完善入组基线至少3次肺功能,记录每次随访日期及肺功能,天气数值,比较每个人不同时期肺功能指标的变化,并找出肺功能变化与天气变化之间关系。采用问卷调查及专业人员随访的方式,每位入组人员需按照随访时间完成肺功能及临床控制CAT评分及呼吸困难mMRC评分,比较不同月份、不同空气颗粒物浓度下患者肺功能及各项评分的不同。结果PM2.5与FEV1/FVC的相关系数为-0.212,P值为0.018(<0.05),与CAT的相关系数为0.318,P值为0.000(<0.05),与mMRC的相关系数为0.619,P值为0.000(<0.05),表明PM2.5与FEV1/FVC存在显著的负向相关,与CAT、mMRC存在显著的正向相关关系。PM10与FEV1/FVC的相关系数为-0.224,P值为0.012(<0.05),与CAT的相关系数为0.304,P值为0.001(<0.05),与mMRC的相关系数为0.584,P值为0.000(<0.05),表明PM10与FEV1/FVC存在显著的负向相关,与CAT、mMRC存在显著的正向相关关系。结论乌鲁木齐市空气污染较重,空气颗粒物可引起慢性阻塞性肺疾病患者肺功能下降,增加呼吸困难程度,进一步造成呼吸系统与肺功能严重损伤,应积极防控空气颗粒物对人体造成的危害。
Objective To investigate the effect of air particles on acute exacerbation and pulmonary function in patients with chronic obstructive pulmonary disease(COPD)in Urumqi.Methods 31 patients with chronic obstructive pulmonary disease admitted to our hospital from 2016 to June 2019 were selected as the objects of investigation,before each subject was enrolled the group,they should perfect the baseline lung function at least 3 times,recorded the date of each follow-up,lung function and weather value.The changes of lung function index in different periods of each person were compared,and the relationship between lung function changes and weather changes was found.By questionnaire survey and professional follow-up,each member of the group should complete the pulmonary function and clinical control CAT score and m MRC score according to the follow-up time,and the lung function and various scores of patients under different months and different air particulate concentrations were compared.Results The correlation coefficient of PM2.5 with FEV1/FVC was-0.212,P value was 0.018(<0.05),with CAT was 0.318,P value was 0.000(<0.05),with MMRC was 0.619,P value was0.000(<0.05),which indicated that PM2.5 had significant negative correlation with FEV1/FVC,and had significant positive correlation with CAT and MMRC.The correlation coefficient between PM10 and FEV1/FVC was-0.224,P value was 0.012(<0.05),with CAT was0.304,P value was 0.001(<0.05),with MMRC was 0.584,P value was 0.000(<0.05).The results showed that PM10 was negatively correlated with FEV1/FVC,and positively correlated with CAT and m MRC.Conclusion Air pollution is serious in Urumqi.Air particles can cause the decline of lung function in patients with chronic obstructive pulmonary disease,increase the degree of dyspnea,and further cause serious damage to respiratory system and lung function.We should actively prevent and control the harm of air particles to human body.
作者
哈依那
牛灵
HA Yina;NIU Ling(People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)
出处
《新疆医学》
2021年第8期944-946,共3页
Xinjiang Medical Journal
基金
新疆维吾尔自治区自然科学基金面上项目(项目编号:2017D01C098)
关键词
慢性阻塞性肺疾病
空气颗粒物
肺功能
chronic obstructive pulmonary disease
air particles
pulmonary function
