摘要
脑肿瘤预后差且治疗困难,为患者和医疗系统带来巨大负担。目前的标准治疗方案是最大范围手术切除辅助放化疗,尽管免疫治疗已广泛应用于肿瘤的治疗,但是由于中枢神经系统的独立性和肿瘤微环境的特殊性,脑肿瘤免疫治疗仍是亟待研究的重要课题。通过对近期出版并翻译的《脑肿瘤免疫治疗及转化研究》进行概述,全面展示近年该领域的重要成果,在吸取研究经验的同时总结发展趋势,为进一步探索脑肿瘤的免疫治疗提供支持。
Brain tumors present poor prognosis and high resistance to treatment,bringingdevastating burden to patients and the health system.The current standard of care includes surgery withassistant chemoradiotherapy.Due to the independence of the central nervous system as well as theuniqueness of tumor microenvironment(TME),it still warrants further studies in immunotherapy of braintumors,despite its broad use in other tumors.This article reviewed the recently published and translatedTranslational Immunotherapy of Brain Tumors and listed the near fundamental results in this fieldgenerally.While learning from the experiences from these researches,we also analyzed the current trendsin brain immunotherapy,promoting successive explorations in immunotherapy of brain tumors.
作者
刘芃昊
王裕
马文斌
LIU Peng hao;WANG Yu;MA Wen bin(Department of Neurosurgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)
出处
《中国现代神经疾病杂志》
CAS
北大核心
2020年第2期79-85,共7页
Chinese Journal of Contemporary Neurology and Neurosurgery
关键词
脑肿瘤
肿瘤微环境
免疫疗法
转化医学研究
综述
Brian neoplasms
Tumor microenvironment
Immunotherapy
Translational medical research
Review
