摘要
细胞周期(cell cycle)是指细胞从一次分裂完成开始到下一次分裂结束所经历的全过程。细胞周期包括G_(0)期(静止期)、G_(1)期(DNA合成前期)、S期(合成期)、G_(2)期(DNA合成后期)和M期(细胞分裂期)。通常,阻止细胞进行异常复制主要有三个检查点,分别为G_(1)/S检查点、G_(2)/M检查点和有丝分裂中/后期检查点。其中,G_(1)/S检查点又称起始点,是细胞周期进程起始的关键节点。G_(1)/S检查点可通过周期蛋白D与CDK4/6结合所形成的复合物调节细胞周期起始,影响细胞周期进程。活性异常的周期蛋白D与CDK4/6会诱导癌细胞的异常增殖,引发癌症恶性发展。因此,了解CDK4/6活性变化情况、周期蛋白D与CDK4/6的组装以及CDK4/6抑制剂的作用,将有助于了解细胞周期进程中潜在的调控过程,并为癌症与疾病的治疗提供一种新方案。该综述对CDK4/6活性调控过程的关键条件,周期蛋白D-CDK4/6在G_(1)期到S期转换中的关键过程,以及CDK4/6类抑制剂治疗药物在癌症及疾病中的研究进展进行了描述与总结,最后阐述了周期蛋白D与CDK4/6在细胞周期进程中所面临的问题及存在的挑战,旨在为后续细胞周期的深入研究提供科学参考。
The cell cycle is the entire process that a cell undergoes from the completion of one decelerated division to the end of the next decelerated division.The cell cycle consists of G_(0)phase(stationary phase),G_(1)phase(DNA pre-synthesis phase),S phase(synthesis phase),G_(2)phase(late DNA synthesis phase)and M phases(cytokinesis).Normally,there are three main checkpoints that prevent cells from undergoing abnormal replication,namely the G_(1)/S checkpoint,the G_(2)/M checkpoint and the metaphase/anaphase mitotic checkpoint.The G_(1)/S checkpoint,also known as the initiation point,is a critical point for cell cycle initiation,and the G_(1)/S checkpoint regulates cell cycle initiation through a complex formed by the binding of cyclin D to CDK4/6,which affects cell cycle progression.In addition,abnormal activity of cyclin D and CDK4/6 can induce abnormal proliferation of cancer cells and trigger malignant development of cancer.Therefore,understanding the changes in CDK4/6 activity,the assembly of cyclin D with CDK4/6 and the role of CDK4/6 inhibitors will help to understand the underlying regulatory processes in cell cycle progression as well as provide a new option for the treatment of cancer.This review describes and summarizes the key conditions for the regulation of CDK4/6 activity,the key processes of cyclin D-CDK4/6 in the G_(1)to S phase transition,and the progress of CDK4/6 inhibitor in cancer,and finally describes the problems and challenges of cyclin D and CDK4/6 in cell cycle progression,aiming to provide a scientific reference for further research on the cell cycle.
作者
张宇飞
潘剑锋
乔永华
戎友俊
马荣
尚方正
张燕军
ZHANG Yufei;PAN Jianfeng;QIAO Yonhua;RONG Youjun;MA Rong;SHANG Fangzheng;ZHANG Yanjun(College of Vocational and Technical,Inner Mongolia Agricultural University,Baotou 014109,China;Department of Animal Genetic Breeding and Reproduction,College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China;Agriculture and Animal Husbandry Bureau of Aohan Banner,Chifeng 026000,China;Key Laboratory of Mutton Sheep&Goat Genetics and Breeding,Ministry of Agriculture and Rural Affairs,Hohhot 010018,China;Inner Mongolia Engineering Research Center for Goat Genetics and Breeding,Hohhot 010018,China;Inner Mongolia Key Laboratory of Sheep&Goat Genetics,Breeding and Reproduction,Hohhot 010018,China;Inner Mongolia Key Laboratory of Animal Genetics Breeding and Reproduction in Universities,Hohhot 010018,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2023年第11期1715-1722,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:32260816)
内蒙古自治区高等学校创新团队发展计划(批准号:NMGIRT2322)资助的课题
