摘要
随着社会生活压力的增大,焦虑症逐渐成为当代最常见的精神类疾病之一。焦虑症的发病机制涉及多个系统功能的调节紊乱,并且人类的多个脑区参与焦虑的发生。NMDA受体是由7种不同的亚基组成的多聚体复合物,介导着中枢神经系统的兴奋性神经传递,并且其不同亚基在焦虑症的发病机制中均发挥着重要作用。此外,焦虑症动物模型的相关研究已经表明,NMDA受体通过影响恐惧条件反射以及恐惧消退来参与焦虑的产生。该文旨在介绍焦虑症中NMDA受体不同亚基表达水平及其下游信号通路发生的变化,以及氯胺酮、美金刚和D-环丝氨酸等NMDA受体相关药物在治疗焦虑症方面的研究进展。
With the increasing pressure of social life,anxiety has gradually become one of the most common mental diseases.The pathogenesis of anxiety disorder involves the regulation disorder of many system functions,and many brain areas of human participate in the occurrence of anxiety.NMDA receptor is a polymeric complex composed of seven different subunits that mediate excitatory neurotransmission in the central nervous system,and its different subunits play an important role in the pathogenesis of anxiety disorders.In addition,studies in animal models of anxiety disorders have shown that NMDA receptors are involved in the generation of anxiety by influencing fear conditioning and fear extinction.This article aims to review the expression levels of different NMDA receptor subunits and their downstream signaling pathways in anxiety disorders,as well as the research progress of NMDA receptor related drugs in the treatment of anxiety disorders,such as ketamine,memantine and D-cycloserine.
作者
章帆
舒渝茜
吴凡
鲁娇
王清
赵航
何治
ZHANG Fan;SHU Yuqian;WU Fan;LU Jiao;WANG Qing;ZHAO Hang;HE Zhi(Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine Approveby State Administration of Traditional Chinese Medicine,Yichang 443002,China;Medical College,China Three Gorges University,Yichang 443002,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2022年第11期2190-2198,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金面上项目(批准号:82073824)资助的课题
