摘要
心血管疾病是目前危害全球人类健康的首要风险因素。传统的治疗手段虽能延长患者寿命,但也存在着诸多风险,因此对于心血管疾病的治疗人们需要寻找更为有效的靶点。核仁素是一类广泛表达且高度保守的蛋白质,在多种心血管疾病病理过程中异常表达,直接影响细胞的相关功能,提示核仁素是心血管疾病的潜在治疗靶点。该文就核仁素在心血管疾病发生、发展中的作用加以综述。
The cardiovascular diseases are the leading cause of death worldwide.Although traditional treatment can prolong the life of patients,it is associated with many risks.Therefore,new treatments targeting a universal target are needed to achieve a better effect.Nucleolin is a widely expressed and highly conserved protein,which is abnormally expressed in the pathological process of various cardiovascular diseases.Its abnormal expression directly affects the function of the cells,suggesting that nucleolin is a potential therapeutic target for cardiovascular diseases.This paper reviews the role of nucleolin in the occurrence and development of cardiovascular diseases.
作者
涂均楚
王燕丽
陆琳
吴诚洁
张瑜
李杨欣
TU Junchu;WANG Yanli;LU Lin;WU Chengjie;ZHANG Yu;LI Yangxin(Institute for Cardiovascular Science and Department of Cardiovascular Surgery,First Affiliated Hospital and Medical College of Soochow University,Soochow University,Suzhou 215006,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2022年第11期2164-2170,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:91849122、81870194)
江苏省“六大人才高峰”创新团队项目(批准号:BU 24600117)
中国博士后基金(批准号:2021M702394)
江苏省卓越博士后基金资助的课题
关键词
核仁素
心血管疾病
分子调控机制
nucleolin
cardiovascular disease
molecular mechanism
